Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help. [PDF]
PLoS ONE, 2011 We have previously demonstrated that temporary depletion of CD4 T cells in mice with progressive B16 melanoma, followed by surgical tumor excision, induces protective memory CD8 T cell responses to melanoma/melanocyte antigens.
Anik L Côté +4 more
doaj +1 more source
Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion. [PDF]
, 2013 Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase.
Hundemer, Michael +63 more
core +1 more source
CD3-immunotoxin mediated depletion of T cells in lymphoid tissues of rhesus macaques
Heliyon, 2023 Selective T-cell depletion prior to cell or organ transplantation is considered a preconditioning regimen to induce tolerance and immunosuppression. An immunotoxin consisting of a recombinant anti-CD3 antibody conjugated with diphtheria toxin was used to
Lan Wang +8 more
doaj +1 more source
Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections
Frontiers in Immunology, 2017 The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity that leads ultimately to death.
K. K. Vidya Vijayan +3 more
semanticscholar +1 more source
Maturation and mip-1β production of cytomegalovirus-specific T cell responses in Tanzanian children, adolescents and adults : impact by HIV and Mycobacterium tuberculosis co-infections [PDF]
, 2015 It is well accepted that aging and HIV infection are associated with quantitative and functional changes of CMV-specific T cell responses. We studied here the expression of Mip-1β and the T cell maturation marker CD27 within CMVpp65-specific CD4+ and CD8+
Elmar Saathoff +49 more
core +1 more source
Major CD4 T-Cell Depletion and Immune Senescence in a Patient with Chronic Granulomatous Disease
Frontiers in Immunology, 2017 Chronic granulomatous disease (CGD) results from primary defects in phagocytic reactive oxygen species (ROS) production. T-cell evaluation is usually neglected during patients’ follow-up, although T-cell depletion has been reported in CGD through unknown
Adriana S. Albuquerque +16 more
doaj +1 more source
Frontiers in Genetics, 2022 Despite the recent increase in the use of immune checkpoint blockade (ICB), no ICB medications have been approved or are undergoing large-scale clinical trials for glioma.
Lie Chen, Biao Fu
doaj +1 more source
Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. [PDF]
, 2007 Investigation of the role of regulatory T cells (Treg) in model systems is facilitated by their depletion using anti-CD25 Abs, but there has been considerable debate about the effectiveness of this strategy.
Couper, Kevin N +9 more
core +1 more source
Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse. [PDF]
PLoS ONE, 2014 Actin depolymerizing factor-homology (ADF-H) family proteins regulate actin filament dynamics at multiple cellular locations. Herein, we have investigated the function of the ADF-H family member coactosin-like 1 (COTL1) in the regulation of actin ...
Joanna Kim +8 more
doaj +1 more source
Studies on the role of Coronin 1 and the actin cytoskeleton in T cell signaling and survival [PDF]
, 2009 Calcium ions (Ca2+) function as universal second messengers in most if not all eukaryotic cells, including the cells of the immunesystem. Ca2+ signals are required for the proper activation of lymphocytes, such as T-lymphocytes, their proliferation ...
Müller, Philipp
core +1 more source