Results 11 to 20 of about 2,055,767 (301)

Regulatory T-Cell Depletion in Angioimmunoblastic T-Cell Lymphoma [PDF]

The American Journal of Pathology, 2010
Angioimmunoblastic T-cell lymphoma (AITL) is the most frequent nodal T-cell lymphoma and is characterized by a polymorphic lymph node infiltrate, various dysimmune disorders, and a poor prognosis. Regulatory T-cells (Treg) play an emerging role in the prognosis of non-Hodgkin B-cell lymphoma and mediate significant autoreactive T-cell suppression.
Bruneau, Julien, Canioni, D., Renand, A., Marafioti, T., Paterson, J.C., Martin-Garcia, N., Gaulard, P., Delfau, M.H., Hermine, O., Macintyre, E., Brousse, N., Asnafi, V.   +11 more
openaire   +4 more sources

Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared to CD3-targeted T-cell depletion

Transplant Infectious Disease, 2018
T‐cell depletion (TCD) effectively reduces severe graft‐versus‐host disease in recipients of HLA‐mismatched allografts. However, TCD is associated with delayed immune recovery and increased infections.
B. Triplett, Bradley Muller, G. Kang, Y. Li, Shane J. Cross, Joseph Moen, L. Cunningham, W. Janssen, Ewelina Mamcarz, D. Shook, A. Srinivasan, J. Choi, R. Hayden, W. Leung   +13 more
semanticscholar   +2 more sources

Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease

Biomedicines, 2017
Graft versus host disease (GVHD) represents a major complication of allogeneic hematopoietic stem cell transplantation (allo HCT). Graft cellular manipulation has been used to mitigate the risk of GVHD.
H. Abdelhakim, H. Abdel-Azim, A. Saad
semanticscholar   +2 more sources

Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies. [PDF]

PLoS Pathogens, 2009
The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection.
Takeo Kuwata, Yoshiaki Nishimura, Sonya Whitted, Ilnour Ourmanov, Charles R Brown, Que Dang, Alicia Buckler-White, Ranjini Iyengar, Jason M Brenchley, Vanessa M Hirsch   +9 more
doaj   +1 more source

Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease

Journal of Clinical Oncology, 2022
PURPOSE Graft-versus-host disease (GVHD) causes morbidity and mortality following allogeneic hematopoietic cell transplantation. Naive T cells (TN) cause severe GVHD in murine models. We evaluated chronic GVHD (cGVHD) and other outcomes in three phase II
M. Bleakley, A. Sehgal, S. Seropian, M. Biernacki, Elizabeth F. Krakow, Ann Dahlberg, H. Persinger, Barbara Hilzinger, P. Martin, P. Carpenter, M. Flowers, J. Voutsinas, T. Gooley, K. Loeb, B. Wood, S. Heimfeld, S. Riddell, W. Shlomchik   +17 more
semanticscholar   +1 more source

The Role of Regulatory CD4 T Cells in Maintaining Tolerance in a Mouse Model of Autoimmune Hepatitis. [PDF]

PLoS ONE, 2015
The role of regulatory CD4 T cells (Treg) in immune-mediated liver disease is still under debate. It remains disputed whether Treg suppress T cell-mediated hepatitis in vivo and whether hepatic regulatory T cells are functional in patients with ...
Ira An Haack, Katja Derkow, Mathias Riehn, Marc-Nicolas Rentinck, Anja A Kühl, Seija Lehnardt, Eckart Schott   +6 more
doaj   +1 more source

Regulatory T cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis.

Cancer Discovery, 2020
Regulatory T cells (Tregs) are abundant ion human and mouse pancreatic cancer. To understand the contribution to the immunosuppressive microenvironment, we depleted Tregs in a mouse model of pancreatic cancer. Contrary to our expectations, Treg depletion
Yaqing Zhang, J. Lazarus, N. Steele, Wei Yan, Ho-Joon Lee, Z. Nwosu, Christopher J. Halbrook, Rosa E. Menjivar, Samantha B. Kemp, Veerin R. Sirihorachai, Ashley Velez-Delgado, Katelyn L. Donahue, Eileen S. Carpenter, Kristee L Brown, Valerie M. Irizarry-Negron, Anna C. Nevison, A. Vinta, Michelle A. Anderson, H. Crawford, C. Lyssiotis, T. Frankel, Filip Bednar, M. Pasca di Magliano   +22 more
semanticscholar   +1 more source

Targeting lymphotoxin depletes pathogenic T cells [PDF]

Nature Medicine, 2009
A monoclonal antibody directed against lymphotoxin-α (LT-α) expressed by pathogenic T cells can prompt the clearance of these cells from the body (pages 766–773). The findings bring us one step closer to targeting only the cell populations that cause harm in autoimmune diseases while leaving beneficial arms of the immune system largely intact.
Anna M, Hansen, Rachel R, Caspi
openaire   +2 more sources

The Evolution of T Cell Depleted Haploidentical Transplantation [PDF]

Frontiers in Immunology, 2019
Work on bone marrow transplantation from haploidentical donor has been proceeding for over 20 years all over the world and new transplant procedures have been developed. To control both graft rejection and graft vs. host disease, some centers have preferred to enhance the intensity of the conditioning regimens and the post-transplant immune suppression
Franco Aversa, Antonio Pierini, Loredana Ruggeri, Massimo Fabrizio Martelli, Andrea Velardi   +4 more
openaire   +3 more sources

CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

Journal of Experimental Medicine, 2004
The mechanisms underlying CD4+ T cell depletion in human immunodeficiency virus (HIV) infection are not well understood. Comparative studies of lymphoid tissues, where the vast majority of T cells reside, and peripheral blood can potentially illuminate ...
J. Brenchley, T. Schacker, Laura E. Ruff, D. Price, Jodie H. Taylor, G. Beilman, P. Nguyen, A. Khoruts, Matthew Larson, A. Haase, D. Douek   +10 more
semanticscholar   +1 more source