Results 1 to 10 of about 2,055,767 (301)
Frontiers in Immunology, 2021 CD4+ T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted by antiretroviral therapy (ART), particularly if initiated when T ...
Quentin Le Hingrat +6 more
doaj +2 more sources
Regulatory T cells and T cell depletion: role of immunosuppressive drugs. [PDF]
Journal of the American Society of Nephrology, 2007 Allogeneic immune responses are modulated by a subset of host T cells with regulatory function (Treg) contained within the CD4(+)CD25(high) subset. Evidence exists that Treg expand after peritransplantation lymphopenia, inhibit graft rejection, and induce and maintain tolerance.
M. Noris +12 more
semanticscholar +4 more sources
T-cell depletion of HLA-identical transplants in leukemia. [PDF]
Blood, 1991 We analyzed the effects of T-cell depletion on the outcome of HLA- identical sibling bone marrow transplants for leukemia by comparing 731 T-cell-depleted transplants with 2,480 non-T-cell-depleted transplants. T-cell depletion decreased acute graft-versus-host disease (GVHD) (relative risk [RR] 0.45; P less than .0001) and chronic (GVHD) (RR 0.56; P ...
A. M. Marmont +22 more
semanticscholar +4 more sources
Transient T cell depletion causes regression of melanoma metastases [PDF]
Journal of Translational Medicine, 2008 Background Cognate immunity against neoplastic cells depends on a balance between effector T cells and regulatory T (Treg) cells. Treg cells prevent immune attack against normal and neoplastic cells by directly suppressing the activation of effector CD4+
Lear Sheron C +10 more
doaj +3 more sources
Time scales of CD4+ T cell depletion in HIV infection. [PDF]
PLoS Medicine, 2007 Rob De Boer discusses a new study that investigated whether a runaway process of T cell activation/infection would be compatible with the slow time scale of memory CD4(+) T cell depletion in humans with chronic HIV infection.
Rob J De Boer
doaj +6 more sources
Cutting-edge approaches to B-cell depletion in autoimmune diseases
Frontiers in ImmunologyB-cell depletion therapy (BCDT) has been employed to treat autoimmune disease for ~20 years. Immunoglobulin G1 (IgG1) monoclonal antibodies targeting CD20 and utilizing effector function (eg, antibody-dependent cellular cytotoxicity, complement-dependent
William H. Robinson +8 more
doaj +3 more sources
Selective depletion of naïve T cells by targeting CD45RA
Frontiers in Oncology, 2023 Swati Naik, Brandon M. Triplett
doaj +3 more sources
CD3/CD19 Depletion for T-cell Reduction of Allogeneic Transplants: Mostly Efficient, but not Robust
Clinical Hematology International, 2021 Aggressive T-cell depletion, in vitro or in vivo, is a prerequisite for survival of haplo-identical stem cell transplantation. The classical T-cell-depleted transplant, immunomagnetically enriched CD34+ cells, is very safe with respect to graft-versus ...
Eliza Wiercinska +2 more
doaj +1 more source
Heliyon, 2022 Compelling evidence suggests a crucial role for Foxp3+ regulatory T cells (Tregs) in the control of atherosclerosis. Although suppression of pro-inflammatory CD4+ T cell immune responses is supposed to be important for athero-protective action of Foxp3 ...
Kazuyuki Kasahara +7 more
doaj +1 more source