Results 21 to 30 of about 2,055,767 (301)

Understanding the slow depletion of memory CD4(+) T cells in HIV infection [PDF]

, 2007
Background The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood.
Nigel Klein, Klein Nigel, Antia, Rustom, Yates, Andrew, Callard, Robin, Antia Rustom, Yates, A, Callard, R, Klein, Nigel, Jaroslav Stark, Stark, J, Andrew Yates, Stark Jaroslav, Rustom Antia, Callard Robin, Stark, Jaroslav, Yates Andrew, Robin Callard, Klein, N, Antia, R   +19 more
core   +1 more source

Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens

PLoS Pathogens, 2021
Regulatory T (Treg) cells, which constitute about 5–10% of CD4+T cells expressing Foxp3 transcription factor and CD25(IL-2 receptor α chain), are key regulators in controlling immunological self-tolerance and various immune responses.
Ryuta Uraki, Masaki Imai, Mutsumi Ito, Hiroaki Shime, Mizuyu Odanaka, Moe Okuda, Yoshihiro Kawaoka, Sayuri Yamazaki   +7 more
doaj   +3 more sources

Mathematical analysis of affinity hemodialysis on T-Cell depletion

Scientific African, 2020
Investigation into the mathematical analysis of affinity hemodialysis on T-cell depletion is considered to give more significant understanding on the infection dynamics of HIV.
A.M. Okedoye, S.O. Salawu, S.I. Oke, N.K. Oladejo   +3 more
doaj   +1 more source

Immunologic Control of Mus musculus Papillomavirus Type 1. [PDF]

PLoS Pathogens, 2015
Persistent papillomas developed in ~10% of out-bred immune-competent SKH-1 mice following MusPV1 challenge of their tail, and in a similar fraction the papillomas were transient, suggesting potential as a model.
Joshua W Wang, Rosie Jiang, Shiwen Peng, Yung-Nien Chang, Chien-Fu Hung, Richard B S Roden   +5 more
doaj   +1 more source

Pyroptosis drives CD4 T-cell depletion in HIV-1 infection

Nature, 2013
The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism. We now show that caspase-3-mediated apoptosis accounts for the death of only a small fraction of CD4 T cells ...
G. Doitsh, N. Galloway, X. Geng, Zhiyuan Yang, K. Monroe, O. Zepeda, P. Hunt, H. Hatano, S. Sowinski, Isa Muñoz-Arias, W. Greene   +10 more
semanticscholar   +1 more source

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

Journal of Experimental Medicine, 1999
To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was on average a 99.9% reduction of
Xia Jin, Daniel E. Bauer, Sarah Tuttleton, S. Lewin, A. Gettie, J. Blanchard, C. Irwin, J. Safrit, J. Mittler, L. Weinberger, L. Kostrikis, Linqi Zhang, A. Perelson, D. Ho   +13 more
semanticscholar   +1 more source

In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. [PDF]

PLoS Pathogens, 2010
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms.
Joseph K Wong, Matthew C Strain, Rodin Porrata, Elizabeth Reay, Sumathi Sankaran-Walters, Caroline C Ignacio, Theresa Russell, Satish K Pillai, David J Looney, Satya Dandekar   +9 more
doaj   +1 more source

Long-Term Survival of Pig-to-Rhesus Macaque Renal Xenografts is Dependent on CD4 T cell Depletion

American Journal of Transplantation, 2019
The shortage of available organs remains the greatest barrier to expanding access to transplant. Despite advances in genetic editing and immunosuppression, survival in experimental models of kidney xenotransplant has generally been limited to 400 days vs
Steven C Kim, David V. Mathews, Cynthia P. Breeden, Laura B. Higginbotham, J. Ladowski, G. Martens, A. Stephenson, Alton B. Farris, E. Strobert, J. Jenkins, E. Walters, C. Larsen, M. Tector, A. Tector, A. Adams   +14 more
semanticscholar   +1 more source

Clinical grade purification and expansion of NK cell products for an optimized manufacturing protocol

Frontiers in Oncology, 2013
Allogeneic Natural Killer (NK) cells are used for adoptive immunotherapy after stem cell transplantation. In order to overcome technical limitations in NK cell purification and activation, the following study investigates the impact of different ...
Ulrike eKoehl, Claudia eBrehm, Sabine eHuenecke, Stephan eKloess, Melanie eBremm, Stefanie Yvonne eZimmermann, Evelyn eUllrich, Jan eSoerensen, Andrea eQuaiser, Stephanie eErben, Claudia eWunram, Tanja eGardlowski, Eileen eAuth, Eileen eAuth, Torsten eTonn, Chritian eSeidl, Sandrine eMeyer-Monard, Martin eStern, Jakob ePassweg, Thomas eKlingebiel, Peter eBader, Dirk eSchwabe, Ruth eEsser   +22 more
doaj   +1 more source

T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice

Disease Models & Mechanisms, 2015
Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells.
Ceri E. Oldreive, Anna Skowronska, Nicholas J. Davies, Helen Parry, Angelo Agathanggelou, Sergey Krysov, Graham Packham, Zbigniew Rudzki, Laura Cronin, Katerina Vrzalikova, Paul Murray, Elena Odintsova, Guy Pratt, A. Malcolm R. Taylor, Paul Moss, Tatjana Stankovic   +15 more
doaj   +1 more source