Results 251 to 260 of about 2,055,767 (301)
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The dynamics of CD4+ T-cell depletion in HIV disease
Nature, 2001The size and composition of the CD4+ T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4+ T cells are instead depleted. Such depletion cannot result simply from accelerated destruction of mature CD4+ T
J. McCune
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Chylothorax Causing Reversible T-cell Depletion
The Journal of Trauma: Injury, Infection, and Critical Care, 1988Study of a patient with traumatic chylothorax after blunt chest trauma defines the changes in cellular immunocompetence during nonoperative management and emphasizes the importance of defining these parameters in addition to documenting the effects of metabolic deterioration.
J R, Breaux, C, Marks
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T‐CELL DEPLETION OF HUMAN BONE MARROW
International Journal of Immunogenetics, 1989SUMMARYThe myelo‐ablative effects of high‐dose therapy for refractory cancer can be overcome by the transplantation of bone marrow from an HLA‐matched normal donor. Suitable donors are available for only one patient in three, and even minor disparities at HLA loci can produce graft‐versus‐host disease (GvHD) in transplant recipients.
A P, Gee, V, Mansour, M, Weiler
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Depletion of Human Regulatory T Cells
2011Regulatory T cells (Treg) have become increasingly relevant in the study of human disease including cancer. Treg cells have been shown to inhibit anti-tumor immune responses, and elevated Treg levels have been associated with certain types of cancer. Similarly, depletion of Tregs by various methods can also enhance anti-tumor immune responses.
Amy C, Hobeika +5 more
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Blood, 2005
Comment on Pavletic et al, page [3308][1] After more than two decades of clinical practice, we finally have results from the first randomized study of T-cell depletion of donor marrow before allogeneic transplantation.
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Comment on Pavletic et al, page [3308][1] After more than two decades of clinical practice, we finally have results from the first randomized study of T-cell depletion of donor marrow before allogeneic transplantation.
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Repertoire Remodeling through CD4+ T-cell Depletion
Cancer Immunology Research, 2021Abstract Understanding the cellular regulation of tumor-specific CD8+ T-cell responses is critical to designing improved clinical strategies for cancer immunotherapy. In this issue, Aoki and colleagues deepen our knowledge of this topic by demonstrating that transient depletion of CD4+ T cells in patients with gastrointestinal cancer ...
Winnie Yao, Ansuman T. Satpathy
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Negative depletion of CD3+ and TcRαβ+ T cells
Current Opinion in Hematology, 2012In contrast to CD34(+) positive selection, negative depletion strategies retain large numbers of effector cells in allogeneic peripheral stem cell grafts, such as natural killer (NK) and other cells. This review summarizes the clinical experience obtained using negative depletion approaches of CD3(+) and T-cell receptor (TcR)αβ(+) T lymphocytes ...
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CD4+ T-cell Depletion Prevents GVHD
Cancer Discovery, 2017Abstract Temporary removal of CD4+ T cells after an allogeneic hematopoietic stem-cell transplant leads to changes in the nature of CD8+ T cells that, according to a mouse study, help prevent graft-versus-host disease without jeopardizing the therapy's potential to eliminate leukemia or lymphoma.
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Effect of T cell depletion on the potentiated reagin response
Nature, 1974IN the rat, infection with helminth parasites can have the remarkable effect of causing nonspecific potentiation of IgE (reaginic) antibody responses against antigens unrelated to those of the parasite. This phenomenon, which has been called the potentiated reagin response1, has been found to encompass IgE responses to antigens as diverse as egg ...
E, Jarrett, A, Ferguson
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In Vivo Depletion of Chicken T‐Cell Subsets
Scandinavian Journal of Immunology, 1993In the chicken three types of T‐cell receptors can be defined by monoclonal antibodies TCR1, TCR2 and TCR3, which recognize γδ T cells, and Vβ1‐ and Vβ2‐expressing αβ T cells, respectively. In the present report we have analysed means of selectively depleting the γδ T cells and the Vβ1 +αβ T cells.γδ cells, which represent up to 66% of all T cells in ...
J, Cihak +5 more
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