Results 261 to 270 of about 2,055,767 (301)
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Induction of Autoimmune Disease by Depletion of Regulatory T Cells
Current Protocols in Immunology, 1999AbstractOrgan‐specific autoimmune diseases can be induced in rodents that do not normally spontaneously develop autoimmunity by using procedures that render the animals partially T cell deficient. Using a protocol of adult thymectomy followed by four doses of sublethal gamma irradiation, insulin‐dependent diabetes can be induced in normal PVG.RT1u rats,
S, Simmonds, D, Mason
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Engraftment of T-Cell-Depleted Rabbit Bone Marrow
Acta Haematologica, 2009T cell depletion of donor bone marrow prevents graft-versus-host disease (GvHD) but increases the risk of rejection. Rabbit bone marrow was T-cell-depleted using the properties of rabbit T cells to form spontaneous rosettes in the cold and by incubation in methylprednisolone (1 mg/ml, 106 cells/ml).
A, Gratwohl +3 more
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CD34+ Enrichment and T-Cell Depletion
2017For many patients with hematological or solid organ malignancies, stem cell transplant is a critical component of their treatment. The field of hematopoietic cell transplantation is rapidly evolving as is our understanding of cellular immunity. Along with this knowledge has come the ability to engineer hematopoietic progenitor cell (HPC) grafts ...
Scott T. Avecilla, Cheryl A. Goss
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Differential effects of glutathione depletion on T cell subsets
Cellular Immunology, 1991Glutathione (GSH) is known to play an important role in various lymphocyte functions. We now report that different T cell subsets express different requirements for intracellular GSH. Depletion of intracellular GSH by buthionine sulfoximine (BSO), a specific inhibitor of GSH biosynthesis, decreases the proportion of CD8+ cells (i.e., increases the CD4+/
H, Gmünder, W, Dröge
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Selective Allo-depletion: TcRαβ and CD19+ T-Cell Depletion
2018Haploidentical hematopoietic cell transplantation is a curative alternative option for patients without an otherwise HLA-matched suitable donor. In order to prevent graft-versus-host disease, different in vitro and in vivo T-cell depletion strategies have been developed. A delayed immune reconstitution is common to all these strategies, and an impaired
Franco Aversa +2 more
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Guanine Ribonucleotide Depletion Inhibits T Cell Activation
1991Mizoribine is an immunosuppressive drug (4-carbamoyl-1-s-Dribofuranosylimidazolium-5-olate, also known as bredinin) which has been demonstrated to be beneficial in organ transplantation. In animal models: canine renal allografts, and rat cardiac and partial lung allografts, mizoribine is synergistic with cyclosporine in prolonging survival1,2 ...
J S, Dayton +3 more
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Antigen processing and CD4+ T cell depletion in AIDS
Cell, 1988e infection of T lymphocytes by HIV-1 can be blocked by anti-CD4 monoclonal antibodies (Dalgleish et al., Nature 372,763-767,1984; Klatzmann et al., ibid., 767-768); * HIV-1 envelope (env) giycoprotein (gp120) binds specifically to the CD4 molecule present on helper/inducer T lymphocytes (McDougal et al., Science 237, 382-385, 1986); and expression of ...
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Depletion of Suppressor T-Cells in Syngeneic Chimeric Mice
1976The present results suggest that some T-cell activities of syngeneic chimeric mice such as T-cells involved in the antibody response to SRBC and MLC reaction are intact. On the other hand, suppressor T-cells involved in the regulation of the immune response to PVP and enhancement of 3LL tumor growth, and cells mediating CML reaction are damaged.
V, Rotter, N, Trainin
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Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond
Leukemia, 2007M. Mohty
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