A multifunctional T-cell engager containing CD80 enhances prostate cancer treatment. [PDF]
Nie D +12 more
europepmc +1 more source
Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon +5 more
wiley +1 more source
Chimeric PRR T-cell-engager targeting cell surface β-1,3-glucan for invasive candidiasis. [PDF]
Sun YF +8 more
europepmc +1 more source
The intrinsic distortion‐rich lattice of HEPBA with GQD‐enabled microstrain engineering establishes a mechanistic route toward high‐performance alkaline hydrogen evolution reaction. HEPBA inherently feature heterogeneous local coordination environments arising from multimetal incorporation, while properly introducing GQD during coprecipitation ...
Mia Rinawati +10 more
wiley +1 more source
Erratum: Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect in vivo. [PDF]
Zhong L +13 more
europepmc +1 more source
Chemically Fueled Systems Chemistry Across Length Scales
Chemically fueled reaction cycles regulate processes through single and multiple catalytic sites on the molecular and assembly scale. This gives rise to unique kinetically controlled properties/functions like spatio‐temporal catalysis, oscillations, optical properties, and perform work.
Brigitte A. K. Kriebisch, Job Boekhoven
wiley +1 more source
Targeting IL13Rα2 in melanoma with a bispecific T-cell engager: expression profiling and preclinical evaluation. [PDF]
Zhao S +8 more
europepmc +1 more source
Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy +7 more
wiley +1 more source
Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy. [PDF]
Dong Z +11 more
europepmc +1 more source
Multifunctional solid polymer electrolyte (SPE) films integrating intrinsic self‐healing, mechanical stretchability, and dual photo‐ and pH‐responsive ionic conductivity are developed. Constructed from thermoplastic polyurethane (TPU) and hydrogen‐bonded poly(thiourea triethylene glycol) (PTUEG3), these films form a dynamic supramolecular network ...
Mei‐Li Li +12 more
wiley +1 more source

