Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease. [PDF]
Yokoi E+11 more
europepmc +1 more source
In vitro lymphocyte-differentiating effects of thymulin (Zn-FTS) on lymphocyte subpopulations of severely malnourished children [PDF]
Bustos, M.+6 more
core +1 more source
An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy
This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma+14 more
wiley +1 more source
Tertiary lymphoid structures in gliomas: impact on tumour immunity and progression. [PDF]
Chen J, Yang Y, Luan S, Xu W, Gao Y.
europepmc +1 more source
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song+37 more
wiley +1 more source
Fibroblast heterogeneity and its role in generating protective immunity in the secondary lymphoid organs. [PDF]
Yasmin H+3 more
europepmc +1 more source
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan+9 more
wiley +1 more source
Immunomodulatory Effect of Phage Depolymerase Dep_kpv74 with Therapeutic Potential Against K2-Hypervirulent Klebsiella pneumoniae. [PDF]
Volozhantsev NV+7 more
europepmc +1 more source
Thymulin (Zn-FTS) activity in protein-energy malnutrition : new evidence for interaction between malnutrition and infection on thymic function [PDF]
Bleiberg-Daniel, F.+7 more
core +1 more source