Results 81 to 90 of about 164,918 (277)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance

International Journal of Organ Transplantation Medicine, 2014
T cell differentiation is dictated by a combination of T cell receptor (TCR) interaction with an antigen-bound major histocompatibility complex (MHC), and co-stimulatory molecules signal.
R Abdoli, N Najafian
doaj  

Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells [PDF]

, 2017
CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and
Adhikary, Adhikary, Adhikary, Ahn, Anderson, Annunziato, Appay, Appay, Aslan, Balfour, Battaglia, Baumjohann, Bickham, Bosselut, Britt, Brown, Brown, Brown, Brown, Brown, Bui, Cao, Cao, Cao, Carpenter, Casazza, Chen, Cheroutre, Chiu, Coler, de Souza, Deligeoroglou, Demachi-Okamura, Depil, Devarajan, Di Mitri, Dillon, Draenert, Duftner, Dumitriu, Endo, Enssle, Eshima, Facchinetti, Farrar, Faè, Fishman, Fleischer, Fontenot, Freeman, Fu, Fu, Gamadia, Gao, Garcia-Chagollan, Gasser, Geginat, Gelband, Goonetilleke, Grabowska, Grakoui, Grant, Grant, Groh, Ha, Haigh, Haque, Heaton, Hegde, Heller, Heusinkveld, Hildemann, Hislop, Hohler, Homma, Houser, Hua, Huz, Icheva, James, Jameson, Jeitziner, Johnson, Jones, Jones, Jonjic, Kadish, Kannanganat, Kaufmann, Kayagaki, Kenter, Kenter, Khanolkar, King, King, Kobayashi, Koel, Krensky, Kroesen, Kruger, Kuroda, Lazdina, Li, Libri, Lin, Loewendorf, Long, Long, Long, Long, Luckheeram, Lunemann, MacArthur, Mackay, Magnani, Malnati, Man, Manzke, Marshall, Martorelli, Mattapallil, McKinstry, McMichael, Merlo, Merlo, Metkar, Miamen, Moormann, Morales, Mosmann, Mucida, Munz, Munz, Murphy, Musey, Namekawa, Nemes, Nikiforow, Nixon, Norris, Oestreich, Omiya, O’Shea, Pachnio, Pachnio, Paludan, Pender, Peng, Penna, Piriou, Plata, Porakishvili, Qui, Quigley, Ratto-Kim, Reis, Rentenaar, Rerks-Ngarm, Ressing, Rosenberg, Sacha, Sakaguchi, Sallusto, Sandbulte, Savic, Scherrenburg, Schueller, Schulze zur Wiesch, Schulze Zur Wiesch, Schwartz, Seresini, Seresini, Soghoian, Soghoian, Spaete, Stacey, Steele, Streeck, Stuller, Su, Sun, Tagawa, Takeuchi, Tenzer, Terahara, Tewari, Thursz, Todryk, Tong, Toussirot, Trautmann, Trautmann, Trifari, Tscharke, Turnbull, Ulsenheimer, Vacchio, van de Berg, van den Hende, van Leeuwen, Vasin, Veldhoen, Ventura, Verma, Veronese, Voo, Voo, Vossen, Walker, Walton, Wang, Wang, Welters, Welters, WHO, Wilkinson, Wilson, Wilson, Wintermeyer, Workman, Xie, Xue, Yan, Yewdell, Zaunders, Zaunders, Zheng, Zhou, Zuo, zur Hausen   +229 more
core   +2 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells

Journal of Experimental Medicine, 1986
Diabetes-prone BioBreeding/Worcester (BB/Wor) rats received thrice weekly injections of mAb against antigens expressed on the surface of all T cells (OX19), cytotoxic/suppressor, and NK cells (OX8), helper/inducer cells (W3/25, OX35, OX38), and Ia+ cells
A. Like, C. Biron, E. J. Weringer, K. Byman, E. Sroczynski, D. Guberski   +5 more
semanticscholar   +1 more source

T-lymphocyte subsets in liver tissues of patients with primary biliary cirrhosis (PBC), patients with primary sclerosing cholangitis (PSC), and normal controls [PDF]

, 1984
T lymphocytes infiltrating hepatic tissues were typed and enumerated in liver biopsies of patients with primary biliary cirrhosis (PBC), patients with primary sclerosing cholangitis (PSC), and normal controls using monoclonal antibodies and the avidin ...
AK Bhan, AP Guebel, D Doniach, David H. Van Thiel, F Paronetto, G Routhier, GR Pape, GS Wood, H Popper, HC Thomas, HC Thomas, HF Eggink, IG McFallane, J Miller, J Sanchez-Tapias, JL Dienstag, L Montano, L Si, Lusheng Si, N Cerf-Bensussan, PA Berg, PL Golding, RK Zetterman, Robert R. Schade, S Hsu, S Sherlock, S Sherlock, SP James, Theresa L. Whiteside, Thomas E. Starzl, V Cancellieri, Y Thomas   +31 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. [PDF]

, 1992
Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response.
Azuma, M, Buck, D, Cayabyab, M, Lanier, LL, Phillips, JH   +4 more
core   +1 more source

DY determinants, possibly associated with novel class II molecules, stimulate autoreactive CD4+ T cells with suppressive activity [PDF]

, 1988
A set of T cell clones (TCC) isolated from HLA-DR-, Dw-, DQ-matched allogeneic MLCs was found to proliferate autonomously when stimulated with cells carrying a wide range of class I or II specificities.
Brocker, Thomas, Fernandez, N., Festenstein, H., Pawelec, G., Schneider, E. M., Wernet, P.   +5 more
core   +2 more sources