Results 281 to 290 of about 807,016 (349)

Evaluation of PD-1 and interleukin-10-receptor expression by T lymphocytes in malignant and benign pleural effusions. [PDF]

Clin Exp Med
Mosleh B, Hammer B, El-Gazzar A, Kramer M, Ayazseven S, Bernitzky D, Geleff S, Idzko M, Gompelmann D, Hoda MA.   +9 more
europepmc   +1 more source

Targeting the Adenosine‐Mediated Metabolic Immune Checkpoint with Engineered Probiotic for Enhanced Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study presents engineered probiotics that convert immunosuppressive adenosine into inosine in tumors, alleviating immunosuppression and enhancing antitumor immunity. Demonstrating efficacy in murine ectopic and orthotopic tumor models, this approach offers a promising probiotic‐based cancer immunotherapy strategy, highlighting the potential of ...
Jinhui Wang, Jing Wang, Zhijie Yu, Hongyu Wen, Chensi Zhao, Jiayong Zhong, Chuanle Xiao, Yingqiu Li, Jianqiao Xu, Jinquan Wang, Zong‐Wan Mao, Wei Xia   +11 more
wiley   +1 more source

Preliminary exploration of the expression of acetylcholinesterase in normal human T lymphocytes and leukemic Jurkat T cells. [PDF]

Biomed Rep
Gómez-Olivares JL, López-Durán RM, Enríquez-Flores S, López-Velázquez G, De La Mora-De La Mora I, García-Torres I, Viedma-Rodríguez R, Valencia-Quintana R, Milić M, Flores-López LA.   +9 more
europepmc   +1 more source

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

Advanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni, Jian Tan, Julen Reyes, Alistair M Senior, Caitlin Andrews, Jemma Taitz, Camille Potier‐Villette, Claire Wishart, Alanna Spiteri, Laura Piccio, Nicholas Jonathan Cole King, Romain Barrès, David Raubenheimer, Stephen James Simpson, Ralph Nanan, Laurence Macia   +15 more
wiley   +1 more source

Delivery of Human iPSC‐Derived RPE Cells in Healthy Minipig Retina Results in Interaction Between Photoreceptors and Transplanted Cells

Advanced Science, EarlyView.
Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová, Francisco Javier Rodriguez‐Jimenez, Annika Konrad, Yaroslav Nemesh, Muhammed Arshad Thottappali, Ana Artero‐Castro, Ruslan Nyshchuk, Anastasiia Kolesnikova, Brigitte Müller, Hana Studenovska, Jana Juhasova, Stefan Juhas, Ivona Valekova, Dunja Lukovic, Claudia Aleman, Taras Ardan, Saskia Drutovič, Jan Motlik, Zdenka Ellederova, Zbinek Straňák, Miroslav Veith, Lyubomyr Lytvynchuk, Ruchi Sharma, Kapil Bharti, Goran Petrovski, Pavla Jendelova, Knut Stieger, Slaven Erceg   +27 more
wiley   +1 more source

Corrigendum: Cytosolic protein translation regulates cell asymmetry and function in early TCR activation of human CD8⁺ T lymphocytes. [PDF]

Front Immunol
Gómez-Morón Á, Tsukalov I, Scagnetti C, Pertusa C, Lozano-Prieto M, Martínez-Fleta P, Requena S, Martín P, Alfranca A, Martin-Gayo E, Martin-Cofreces NB.   +10 more
europepmc   +1 more source

Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma

Advanced Science, EarlyView.
To address the challenge of postoperative recurrence, Combo Gel, a peptide‐based hydrogel that integrates glutamine metabolism modulation with chemodynamic therapy (CDT) is engineered. This innovative system, containing CB‐839 and copper peptide nanoparticles (Cu‐His NPs), enhances CDT's efficacy and promotes immunogenic cell death, thereby ...
Yiran Guo, Tianhe Jiang, Sen Liang, Anhe Wang, Jieling Li, Yi Jia, Qi Li, Jian Yin, Shuo Bai, Junbai Li   +9 more
wiley   +1 more source

Use of Specific T Lymphocytes in Treating Cytomegalovirus Infection in Hematopoietic Cell Transplant Recipients: A Systematic Review. [PDF]

Pharmaceutics
Bandeira TFGS, Marti LC, Rother ET, Correia LR, Machado CM.   +4 more
europepmc   +1 more source

Targeting USP1 Potentiates Radiation‐Induced Type I IFN‐Dependent Antitumor Immunity by Enhancing Oligo‐Ubiquitinated SAR1A‐Mediated STING Trafficking and Activation

Advanced Science, EarlyView.
Targeting USP1 is identified as a strategy that significantly enhances type I IFN‐dependent innate immune response within the TME following radiotherapy. Mechanistically, USP1 inhibition facilitates STING trafficking from ER to Golgi by preserving K27‐linked oligo‐ubiquitination of SAR1A, thereby facilitating efficient activation of the dsDNA‐cGAS ...
Weilin Zhou, Yuxuan Zhao, Wenjing Qin, Weijian Wu, Chenyang Liao, Yiqiu Zhang, Xingli Yang, Xue Chen, Youqiao Wang, Yushan Kang, Jiaxin Wu, Jiaojiao Zhao, Junmin Quan, Xuecen Wang, Xianzhang Bu, Xin Yue   +15 more
wiley   +1 more source

Circulating/cerebrospinal T lymphocytes as indicators of clinical prognosis in intracerebral hemorrhage: A prospective study. [PDF]

Medicine (Baltimore)
Xu Q, Fan S, Wang L, Zheng J, Wan Y, Tian R, Xia J, Zhao Z.   +7 more
europepmc   +1 more source