Results 281 to 290 of about 13,171,622 (345)
Some of the next articles are maybe not open access.
Early T Lymphocyte Progenitors
Annual Review of Immunology, 1996The earliest steps along the pathway leading to T cells in mice and humans are reviewed. These are the steps between the multipotent hemopoietic stem cell (HSC) and the fully committed precursors undergoing T cell receptor (TCR) gene rearrangement. At this level significant differences between adult and fetal lymphopoiesis have been demonstrated.
K, Shortman, L, Wu
openaire +2 more sources
Extrathymic T-lymphocyte development
Experimental Hematology, 2003Chronic exposure to oncostatin M (OM) induces massive thymus-independent extrathymic T-cell development, which takes place solely in the lymph nodes (LN), probably because of the high density of OM receptor on LN postcapillary venules. In contrast to what is observed in other models of extrathymic T-cell development, the proportions of doublenegative ...
Marie-Eve, Blais +5 more
openaire +2 more sources
T-Lymphocyte-fibroblast interactions
Biochemical Society Transactions, 1997At the end of the immune response, activated T-cells are cleared by apoptosis. T-cell apoptosis induced by cytokine deprivation can be inhibited by the addition of exogenous cytokines or by a fibroblast-derived survival factor. Under normal circumstances, fibroblast-mediated T-cell survival may allow persistence of a small number of primed T-cells in ...
J G, Crowston +3 more
openaire +2 more sources
T lymphocyte receptor deficiencies
Current Opinion in Immunology, 1995Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing
D J, Kappes, B, Alarcón, J R, Regueiro
openaire +2 more sources
International Archives of Allergy and Immunology, 1995
Some of the key features of aging effects on T lymphocytes have been illuminated in the last few years from new angles. Experimental evidence indicates a profound increase in the proportion of memory versus naive types of T cells, a decline in the response to activation and in the capacity to enter the cycle, and decline in levels of IL-2, yet an ...
openaire +2 more sources
Some of the key features of aging effects on T lymphocytes have been illuminated in the last few years from new angles. Experimental evidence indicates a profound increase in the proportion of memory versus naive types of T cells, a decline in the response to activation and in the capacity to enter the cycle, and decline in levels of IL-2, yet an ...
openaire +2 more sources
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Nature, 1999F. Sallusto +4 more
semanticscholar +1 more source
Functional diversity of helper T lymphocytes
Nature, 1996A. Abbas, K. Murphy, A. Sher
semanticscholar +1 more source
T Lymphocytes and Autoimmunity
2018T lymphocytes play a central role in regulation of the immune system. Both effector and regulatory T cells work in equilibrium to provide optimal immune response against foreign pathogens. Normally, T cells do not react against self-antigens because of the presence of central and peripheral immunogenic tolerance.
Uqba, Khan, Hareem, Ghazanfar
openaire +2 more sources
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Science, 1996J. Altman +7 more
semanticscholar +1 more source