Results 91 to 100 of about 33,656,568 (290)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Transcriptomic analysis of regulatory mechanisms in the telogen-anagen transition of ovine hair follicles

BMC Genomics
Background Dorper sheep are celebrated for their fast maturation and superior meat quality, with some shedding their wool each spring. Wool shedding occurs naturally due to the hair follicle (HF) cycle, but its regulatory mechanisms remain unclear and ...
Ningyue Zhang, Yifan Wang, Jiankui Wang, Liang Zhang, Haoran Sun, Xiaochun Yuan, Siyu Wang, Chunguang Wang, Xinhai LI   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Co-expression of nuclear and cytoplasmic HMGB1 is inversely associated with infiltration of CD45RO+ T cells and prognosis in patients with stage IIIB colon cancer

BMC Cancer, 2010
Background The intratumoral infiltration of T cells, especially memory T cells, is associated with a favorable prognosis in early colorectal cancers. However, the mechanism underlying this process remains elusive.
Yu Xing-Juan, Li Chun-Yan, Ding Ya, Wu Xiao-Jun, Peng Rui-Qing, Zhang Xing, Pan Zhi-Zhong, Wan De-Sen, Zheng Li-Ming, Zeng Yi-Xin, Zhang Xiao-Shi   +10 more
doaj   +1 more source

Pattern classification of valence in depression [PDF]

, 2013
Copyright @ The authors, 2013. This is an open access article available under Creative Commons Licence, CC-BY-NC-ND 3.0.Neuroimaging biomarkers of depression have potential to aid diagnosis, identify individuals at risk and predict treatment response or ...
Johnston, S. J., Linden, D.E.J., Krall, S., Krall, S. C., Linden, David Edmund Johannes, Habes, I, Yuen, KSL, Healy, D., Johnston, S.J., Krall, Sarah C., Krall, SC, Linden, DEJ, Goebel, R.; id_orcid, Healy, David, Healy, D, Habes, I., Sorger, B., Linden, D. E. J., Sorger, B, Johnston, SJ, Habes, Isabelle, Krall, S.C., Yuen, K.S.L., Goebel, R, Yuen, K. S. L., Goebel, R.   +25 more
core   +2 more sources

Different behavioral expression of adolescent male and female rats in Hole-Board evaluated through quantitative and T-pattern analysis

Physiology & Behavior
Studying the behavioral differences between male and female adolescent rats is of paramount importance for gaining a deeper understanding of how sex influences critical biological processes such as stress responses or susceptibility to psychiatric disorders.
Maurizio Casarrubea, Daniel Cassar, Zachary Busuttil, Stefania Aiello, Giuseppe Crescimanno, Giuseppe Di Giovanni   +5 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Forehead, temporal augmentation and lateral browlift with Ellanse M

Journal of Cosmetic Medicine
Background: Ellanse M, a polycaprolactone-based filler, is a versatile collagen stimulator used in aesthetic treatments, particularly for forehead, temporal rejuvenation and lateral brow lifting. We propose a modified forehead classification system (Type
Larry Wu, Bo Wang
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Mutual exclusivity and co-occurrence patterns of immune checkpoints indicate NKG2A relates to anti-PD-1 resistance in gastric cancer

Journal of Translational Medicine
Background An increasing number of clinical studies have begun to explore combination strategies with immune checkpoint inhibitors, aiming to present new opportunities for overcoming anti-PD-1 treatment resistance in gastric cancer.
Guanjun Li, Xiaohan Liu, Chunhui Gu, Guichuang Ma, Shaowei Li, Zhenfeng Ma, Yanqiu Xiong, Yu Jiang, Qiong Huang, Jianhua Wu, Zhenzhen Wu, Wangjun Liao, Qijing Wu, Min Shi   +13 more
doaj   +1 more source