Results 131 to 140 of about 681,261 (380)
Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]
, 2017 Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver +10 more
core +1 more source
Bacille Calmette-Guérin infection in the mouse. Regulation of macrophage plasminogen activator by T lymphocytes and specific antigen. [PDF]
, 1978 Siamon Gordon, Zanvil A. Cohn
openalex +1 more source
iMetaOmics, EarlyView.This study has elucidated the role of three swine acute diarrhea syndrome coronavirus (SADS‐CoV) accessory proteins in influencing viral pathogenicity and preliminarily explored the host molecular targets and pathways affected by the NS3a, NS7a, and NS7b proteins of SADS‐CoV.
Xiaoling Yan +7 more
wiley +1 more source
In vitro characterization of sonothrombolysis and echocontrast agents to treat ischemic stroke
Scientific Reports, 2019 The development of adjuvant techniques to improve thrombolytic efficacy is important for advancing ischemic stroke therapy. We characterized octafluoropropane and recombinant tissue plasminogen activator (rt-PA)-loaded echogenic liposomes (OFP t-ELIP ...
Himanshu Shekhar +7 more
doaj +1 more source
The Journal of Clinical Pharmacology, EarlyView.Abstract Tranexamic acid (TXA) is used for the treatment and occasionally prevention of postpartum hemorrhage (PPH); however, questions still remain regarding dosing regimen optimization. This study evaluated TXA pharmacokinetic (PK) data from four clinical trials (NCT: 04274335, 03287336, 00872469, and 02797119) conducted in pregnant participants ...
Allison Dunn +12 more
wiley +1 more source
Comparative thrombolytic properties of bolus injections and continuous infusions of a chimeric (t-PA/u-PA) plasminogen activator in a hamster pulmonary embolism model [PDF]
, 1991 HR Lu, HR Lijnen, JM Stassen, D Collen
openalex +1 more source
Regulation of plasminogen activation on cell surfaces and fibrin
Journal of Thrombosis and Haemostasis, 2018 The fibrinolytic system dissolves fibrin and maintains vascular patency. Recent advances in imaging analyses allowed visualization of the spatiotemporal regulatory mechanism of fibrinolysis, as well as its regulation by other plasma hemostasis cofactors.
T. Urano, F. Castellino, Yuko Suzuki
semanticscholar +1 more source
Journal of Operations Management, EarlyView.ABSTRACT Stroke is a highly time‐sensitive medical emergency, and earlier treatment is crucial. Drawing on Temporal Motivation Theory, we investigate a “deadline effect” in stroke care and analyze how two deadlines, that is, a medically oriented one (administering Tissue Plasminogen Activator, TPA, within 4.5 h of symptom onset) and a goal‐oriented one
Brandon Lee +2 more
wiley +1 more source
Journal of Orthopaedic Research, EarlyView.ABSTRACT Posttraumatic osteoarthritis (PTOA) is a common sequela to anterior cruciate ligament (ACL) injury in humans and dogs. Identification of conserved targets between species may hasten biomarker identification and therapeutic development. To identify differentially regulated synovial fluid (SF) proteins in ACL injury, SF samples were collected ...
Sydney J. Womack +4 more
wiley +1 more source
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source