Estradiol enhances T-type calcium channel activation in human myometrium telocytes [PDF]
The Journal of Reproduction and Development, 2023 Uterine peristalsis is essential for gamete transport and embryo implantation. It shares the characteristics of spontaneity, rhythmicity, and directivity with gastrointestinal peristalsis.
Lin ZHU +6 more
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Robust switches in thalamic network activity require a timescale separation between sodium and T-type calcium channel activations. [PDF]
PLoS Computational Biology, 2021 Switches in brain states, synaptic plasticity and neuromodulation are fundamental processes in our brain that take place concomitantly across several spatial and timescales.
Kathleen Jacquerie, Guillaume Drion
doaj +2 more sources
T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions [PDF]
Frontiers in Pharmacology, 2023 Neuropathic pain can appear as a direct or indirect nerve damage lesion or disease that affects the somatosensory nervous system. If the neurons are damaged or indirectly stimulated, immune cells contribute significantly to inflammatory and neuropathic ...
Maricruz Rangel-Galván +2 more
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Modeling temperature- and Cav3 subtype-dependent alterations in T-type calcium channel mediated burst firing [PDF]
Molecular Brain, 2021 T-type calcium channels are important regulators of neuronal excitability. The mammalian brain expresses three T-type channel isoforms (Cav3.1, Cav3.2 and Cav3.3) with distinct biophysical properties that are critically regulated by temperature. Here, we
Fernando R. Fernandez +3 more
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Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury [PDF]
Mediators of Inflammation, 2020 Recent studies have illuminated that blocking Ca2+ influx into effector cells is an attractive therapeutic strategy for lung injury. We hypothesize that T-type calcium channel may be a potential therapeutic target for acute lung injury (ALI).
Limei Wan +8 more
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Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia [PDF]
Molecular Brain, 2020 Spinocerebellar ataxia (SCA) 42 is caused by a mutation in CACNA1G, which encodes the low voltage-gated calcium channel CaV3.1 (T-type). Patients with SCA42 exhibit a pure form of cerebellar ataxia. We encountered a patient with the p.Arg1715His mutation,
Naoyuki Hara +6 more
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Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain.
Hak Kyun Yang +9 more
doaj +2 more sources
Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency. [PDF]
Neurobiol Dis, 2021 Dhanalakshmi C +5 more
europepmc +2 more sources
Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators. [PDF]
ACS Pharmacol Transl Sci, 2022 Zhang YL +11 more
europepmc +3 more sources
T-type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation. [PDF]
FEBS Open Bio, 2020 Chen M +9 more
europepmc +2 more sources