Results 121 to 130 of about 183,628 (256)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone. [PDF]

Neuropharmacology, 2021
Coulter I, Timic Stamenic T, Eggan P, Fine BR, Corrigan T, Covey DF, Yang L, Pan JQ, Todorovic SM.   +8 more
europepmc   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Cyclic Peptides as T-Type Calcium Channel Blockers: Characterization and Molecular Mapping of the Binding Site. [PDF]

ACS Pharmacol Transl Sci, 2021
Depuydt AS, Rihon J, Cheneval O, Vanmeert M, Schroeder CI, Craik DJ, Lescrinier E, Peigneur S, Tytgat J.   +8 more
europepmc   +1 more source

Effects of Efonidipine, an L- and T-type Calcium Channel Blocker, on the Renin-Angiotensin-Aldosterone System in Chronic Hemodialysis Patients

, 2010
Nobuyuki Nakano, Toshihiko Ishimitsu, Toshiaki Takahashi, Hideki Inada, Atsushi Okamura, Shuichi Ohba, Hiroaki Matsuoka   +6 more
openalex   +2 more sources

A Mechanism for the Direct Regulation of T-Type Calcium Channels by Ca²⁺/Calmodulin-Dependent Kinase II [PDF]

, 2003
Philip J. Welsby, Hongge Wang, Joshua T. Wolfe, Roger Colbran, Michael L. Johnson, Paula Q. Barrett   +5 more
openalex   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing [PDF]

, 2016
Stuart M. Cain, Soyon Ahn, Esperanza Garcı́a, Yiming Zhang, Zeina Waheed, John R. Tyson, Yi Yang, Trần Văn Sung, Anthony G. Phillips, Terrance P. Snutch   +9 more
openalex   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Monoterpene Indole Alkaloids with Ca_v3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus. [PDF]

Molecules, 2021
Deng ZT, Li WY, Wang L, Zhou ZP, Wu XD, Ding ZT, Zhao QS.   +6 more
europepmc   +1 more source