Results 1 to 10 of about 193,576 (303)

Renzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration [PDF]

Drug Design, Development and Therapy, 2023
Lian Zhong,1,* Xiaoyu Cao,2,* Li Li,1 Yuanyuan He,1 Yanxia Liu,1 Weiwei Chen,1 Fuzhen Yang,1 Ni Xiao,1 Jun Zhang,1 Huifen He3 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of ...
Zhong L, Cao X, Li L, He Y, Liu Y, Chen W, Yang F, Xiao N, Zhang J, He H   +9 more
doaj   +2 more sources

Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels [PDF]

eLife, 2016
The auxiliary α2δ subunits of voltage-gated calcium channels are extracellular membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptides α2 and δ.
Ivan Kadurin, Laurent Ferron, Simon W Rothwell, James O Meyer, Leon R Douglas, Claudia S Bauer, Beatrice Lana, Wojciech Margas, Orpheas Alexopoulos, Manuela Nieto-Rostro, Wendy S Pratt, Annette C Dolphin   +11 more
doaj   +5 more sources

A novel binding site between the voltage-dependent calcium channel CaV1.2 subunit and CaVβ2 subunit discovered using a new analysis method for protein–protein interactions [PDF]

Scientific Reports, 2023
We developed a new method to analyze protein–protein interactions using a dual-inducible prokaryotic expression system. To evaluate protein–protein binding, a chimeric fusion toxin gene was constructed using a DNase-treated short DNA fragment (epitope ...
Agnieszka M. Murakami, Katsuhiro Nagatomo, Ichro Miyoshi, Shirou Itagaki, Yasutaka Niwa, Manabu Murakami   +5 more
doaj   +2 more sources

Bio-inspired voltage-dependent calcium channel blockers. [PDF]

Nat Commun, 2013
Ca(2+) influx via voltage-dependent CaV1/CaV2 channels couples electrical signals to biological responses in excitable cells. CaV1/CaV2 channel blockers have broad biotechnological and therapeutic applications. Here we report a general method for developing novel genetically encoded calcium channel blockers inspired by Rem, a small G-protein that ...
Yang T, He LL, Chen M, Fang K, Colecraft HM.   +4 more
europepmc   +5 more sources

Shear-induced ciliary autotomy mediated by a TRP channel and a voltage-dependent calcium channel [PDF]

iScience
Summary: Cilium, an organelle for sensory transduction and cell motility, dynamically grows and disappears depending on stimulus perception and cell-cycle progression.
Shiyi Hui, Miyu Kimura, Yuya Kadowaki, Miyu Tsuji, Masataka Inoue, Nobuo Watanabe, Kenjiro Yoshimura   +6 more
doaj   +2 more sources

Modulation of L-Type Calcium Currents by Resveratrol-Induced Myogenesis in C2C12 Cells [PDF]

Cells
Skeletal muscle differentiation is tightly regulated by membrane potential dynamics and voltage-dependent ion channel activity. Potassium (K+) and calcium (Ca2+) currents cooperate to orchestrate the transition of myoblasts into fusion-competent myotubes,
Andrea Biagini, Luana Sallicandro, Jasmine Covarelli, Rosaria Gentile, Alessandra Mirarchi, Alessio Farinelli, Gianmarco Reali, Diletta Del Bianco, Paola Tiziana Quellari, Elko Gliozheni, Antonio Malvasi, Giorgio Maria Baldini, Giuseppe Trojano, Claudia Tubaro, Claudia Bearzi, Roberto Rizzi, Cataldo Arcuri, Paolo Prontera, Andrea Tinelli, Bernard Fioretti   +19 more
doaj   +2 more sources

Extracellular acidity and ATP modulate ion currents in human cumulus cells indicating possible roles as metabolic sensors of the follicular microenvironment [PDF]

Physiological Reports
Cumulus cells (CCs), derived from granulosa cells, play a key role in supporting oocyte maturation and development through bidirectional communication. However, their electrophysiological properties in humans are poorly defined.
Andrea Biagini, Rosaria Gentile, Cristina Corbucci, Monica Mariani, Alessandro Favilli, Sandro Gerli, Bernard Fioretti   +6 more
doaj   +2 more sources

Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A. [PDF]

PLoS ONE, 2014
Anoctamin1 (Ano1, or TMEM16A) is a Ca2+-activated chloride channel that is gated by both voltage and Ca2+. We have previously identified that the first intracellular loop that contains a high density of acidic residues mediates voltage- and calcium ...
Qinghuan Xiao, Yuanyuan Cui
doaj   +1 more source

Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin 4 and β3 Subunit in Osteoblasts. [PDF]

PLoS ONE, 2015
Voltage-dependent L-type calcium channels that permit cellular calcium influx are essential in calcium-mediated modulation of cellular signaling. Although the regulation of voltage-dependent L-type calcium channels is linked to many factors including ...
Xuemei Zhang, Fangping Li, Lin Guo, Hongya Hei, Lulu Tian, Wen Peng, Hui Cai   +6 more
doaj   +1 more source

Voltage-dependent calcium channels.

General physiology and biophysics, 2005
Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA). Auxiliary subunits of the HVA calcium channels contribute significantly to biophysical properties of the channels.
LUBICA LACINOVÁ, FRANZ HOFMANN
openaire   +2 more sources