Regulation of CaV1.2 Current: Interaction With Intracellular Molecules
Journal of Pharmacological Sciences, 2007 CaV1.2 (α1c) is a pore-forming subunit of the voltage-dependent L-type calcium channel and is expressed in many tissues. The β and α2/δ subunits are auxiliary subunits that affect the kinetics and the expression of CaV1.2.
Takeshi Kobayashi +4 more
doaj +1 more source
Blockade of current through single calcium channels by trivalent lanthanide cations. Effect of ionic radius on the rates of ion entry and exit. [PDF]
, 1990 Currents flowing through single dihydropyridine-sensitive Ca2+ channels were recorded from cell-attached patches on C2 myotubes. In the presence of dihydropyridine agonist to prolong the duration of single-channel openings, adding micromolar ...
Lansman, JB
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A T-type channel-calmodulin complex triggers αCaMKII activation
Molecular Brain, 2017 Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity.
Hadhimulya Asmara +9 more
doaj +1 more source
The Roles of Calcium Ions in Parkinson’s Disease: Calcium Channel Inhibitors as a Novel Agents?
Journal of Molecular Pathology, 2022 Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons, which results in motor impairment.
Md Reyaz Alam +2 more
doaj +1 more source
FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel [PDF]
, 2001 Hair cells in mouse cochlear cultures are selectively labeled by brief exposure to FM1-43, a styryl dye used to study endocytosis and exocytosis. Real-time confocal microscopy indicates that dye entry is rapid and via the apical surface.
Gale, J.E. +4 more
core +1 more source
Effects of methamphetamine on locomotor activity and thalamic gene expression in leptin-deficient obese mice [PDF]
, 2017 Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons ...
Bisagno, Veronica +3 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits [PDF]
, 2017 Large conductance voltage- and Ca2+-activated K+ (BKCa) channels are essential regulators of membrane excitability in a wide variety of cells and tissues.
England, Sarah K +2 more
core +7 more sources