Results 31 to 40 of about 193,576 (303)

Voltage-dependent calcium channels in the renal microcirculation [PDF]

Nephrology Dialysis Transplantation, 2004
Voltage-dependent calcium channels (Cav) play an important role in the excitation–contraction coupling in vascular smooth muscle by linking hormoneinduced depolarization to calcium influx and contraction. In keeping with this central role of Cav, the channels are targets for pharmacological intervention in conditions such as hypertension.
Boye L, Jensen, Ulla G, Friis, Pernille B, Hansen, Ditte, Andreasen, Torben, Uhrenholt, Jeppe, Schjerning, Ole, Skøtt   +6 more
openaire   +2 more sources

Medaka as a model for ECG analysis and the effect of verapamil

Journal of Pharmacological Sciences, 2018
The heart of the medaka, a small fish native to East Asia, has electrophysiological aspects similar to mammalian hearts. We found that the heart rates of medaka were more similar to humans than mice or rats.
Manabu Yonekura, Nami Kondoh, Chong Han, Yuichi Toyama, Takayoshi Ohba, Kyoichi Ono, Shirou Itagaki, Hirofumi Tomita, Manabu Murakami   +8 more
doaj   +1 more source

Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]

, 1990
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S., Kurtz, Armin, Penner, R., Skott, O.   +3 more
core   +1 more source

A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings

Micromachines, 2020
Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano, Daiki Yamamoto, Mami Asakura, Tohru Hayakawa, Shintaro Mise, Akinobu Matsumoto, Toru Ide   +6 more
doaj   +1 more source

Gene regulation by voltage-dependent calcium channels

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Ca2+ is the most widely used second messenger in cell biology and fulfills a plethora of essential cell functions. One of the most exciting findings of the last decades was the involvement of Ca2+ in the regulation of long-term cell adaptation through its ability to control gene expression.
Barbado, Maud, Fablet, Katell, Ronjat, Michel, de Waard, Michel   +3 more
openaire   +4 more sources

Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundDexmedetomidine is a highly selective α2-adrenoceptor agonist that is widely used for sedation and analgesia during the perioperative period. Intravenous administration of dexmedetomidine induces transient hypertension due to vasoconstriction ...
Seong-Ho Ok, Sung Il Bae, Haeng Seon Shim, Ju-Tae Sohn   +3 more
doaj   +1 more source

MODULATION OF CALCIUM CHANNELS IN ARTERIAL SMOOTH-MUSCLE CELLS BY DIHYDROPYRIDINE ENANTIOMERS [PDF]

, 1993
The actions of the optical enantiomers of BAY K 8644 and Sandoz 202,791 were studied on barium inward currents recorded using the whole-cell configuration of the patch clamp technique from enzymatically isolated smooth muscle cells from the rabbit ear ...
Bolton, TB, Hering, S, Hughes, AD, Timin, EN   +3 more
core   +1 more source

Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current

Channels
L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia, Daniela De Giorgis, Franco Medina, Tamara Hermosilla, Felipe Simon, Diego Varela   +5 more
doaj   +1 more source

A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels. [PDF]

PLoS Genetics, 2008
Dihydropyridines (DHPs) are L-type calcium channel (Ca(v)1) blockers prescribed to treat several diseases including hypertension. Ca(v)1 channels normally exist in three states: a resting closed state, an open state that is triggered by membrane ...
Trevor C Y Kwok, Kwokyin Hui, Wojciech Kostelecki, Nicole Ricker, Guillermo Selman, Zhong-Ping Feng, Peter John Roy   +6 more
doaj   +1 more source

Omega-conotoxin MVIIA reduces neuropathic pain after spinal cord injury by inhibiting N-type voltage-dependent calcium channels on spinal dorsal horn

Frontiers in Neuroscience
Spinal cord injury (SCI) leads to the development of neuropathic pain. Although a multitude of pathological processes contribute to SCI-induced pain, excessive intracellular calcium accumulation and voltage-gated calcium-channel upregulation play ...
Nobuko Ohashi, Daisuke Uta, Masayuki Ohashi, Rintaro Hoshino, Hiroshi Baba   +4 more
doaj   +1 more source