Results 21 to 30 of about 193,576 (303)

Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells [PDF]

, 2004
The effects of auxiliary calcium channel subunits on the expression and functional properties of high-voltage activated (HVA) calcium channels have been studied extensively in the Xenopus oocyte expression system, but are less completely characterized in
Ball S.L., Bangalore R., Barclay J., Canti C., Castellano A., De Waard M., Felix R., Gerster U., Jones O.T., Kamp T.J., Klugbauer N., Neely A., Qian J., Qin N., Rousset M., Shistik E., Stephens G.J., Wakamori M., Williams M.E.   +18 more
core   +1 more source

Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores. [PDF]

PLoS ONE, 2017
Decreased leptin-induced endothelium-dependent vasodilation has been reported in spontaneously hypertensive rats (SHR). Here, we report leptin-induced vasoconstriction in endothelium-denuded pulmonary artery and thoracic aorta from SHR and sought to ...
Samantha Gomart, Caroline Gaudreau-Ménard, Pascale Jespers, Omer Gurkan Dilek, Emeline Hupkens, Aliénor Hanthazi, Robert Naeije, Christian Melot, Nathalie Labranche, Laurence Dewachter, Kathleen Mc Entee   +10 more
doaj   +1 more source

Genetic Evidence Supporting the Role of the Calcium Channel, CACNA1S, in Tooth Cusp and Root Patterning

Frontiers in Physiology, 2018
In this study, we report a unique dominantly inherited disorganized supernumerary cusp and single root phenotype presented by 11 affected individuals belonging to 5 north-eastern Thai families.
Virginie Laugel-Haushalter, Supawich Morkmued, Supawich Morkmued, Corinne Stoetzel, Véronique Geoffroy, Jean Muller, Jean Muller, Anne Boland, Jean-François Deleuze, Kirsley Chennen, Kirsley Chennen, Waranuch Pitiphat, Hélène Dollfus, Hélène Dollfus, Karen Niederreither, Karen Niederreither, Agnès Bloch-Zupan, Agnès Bloch-Zupan, Agnès Bloch-Zupan, Patimaporn Pungchanchaikul   +19 more
doaj   +1 more source

Strategies for studying permeation at voltage-gated ion channels [PDF]

, 1991
Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways.
Lester, Henry A.
core   +1 more source

Molecular Pharmacology of Voltage-Dependent Calcium Channels

Japanese Journal of Pharmacology, 1996
Voltage-dependent Ca2+ channels serve as the only link to transduce membrane depolarization into cellular Ca(2+)-dependent reactions. A wide variety of chemical substances that have the ability to modulate Ca2+ channels have been demonstrated both for their clinic utility and for importance in elucidating the molecular basis of various biological ...
Y, Mori, G, Mikala, G, Varadi, T, Kobayashi, S, Koch, M, Wakamori, A, Schwartz   +6 more
openaire   +3 more sources

Different functions of two putative Drosophila α2δ subunits in the same identified motoneurons

Scientific Reports, 2020
Voltage gated calcium channels (VGCCs) regulate neuronal excitability and translate activity into calcium dependent signaling. The α1 subunit of high voltage activated (HVA) VGCCs associates with α2δ accessory subunits, which may affect calcium channel ...
Laurin Heinrich, Stefanie Ryglewski
doaj   +1 more source

Cinacalcet inhibition of neuronal action potentials preferentially targets the fast inactivated state of voltage-gated sodium channels

Frontiers in Physiology, 2022
Voltage-gated sodium channel (VGSC) activation is essential for action potential generation in the brain. Allosteric calcium-sensing receptor (CaSR) agonist, cinacalcet, strongly and ubiquitously inhibits VGSC currents in neocortical neurons via an ...
Jamie S. Lindner, Jamie S. Lindner, Salil R. Rajayer, Salil R. Rajayer, Briana J. Martiszus, Briana J. Martiszus, Stephen M. Smith, Stephen M. Smith   +7 more
doaj   +1 more source

Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels [PDF]

, 2017
Large conductance Ca(2+)-activated K(+) channels (BK channels) gate open in response to both membrane voltage and intracellular Ca(2+). The channel is formed by a central pore-gate domain (PGD), which spans the membrane, plus transmembrane voltage ...
Adams, Adelman, Alvarez, Atkinson, Bao, Bao, Barrett, Behrens, Braun, Brayden, Brelidze, Brelidze, Budelli, Butler, Cox, Cui, Cui, Ferguson, Guohui Zhang, Hite, Hite, Horrigan, Horrigan, Hu, Hudspeth, Hudspeth, Jianmin Cui, Jingyi Shi, Karl L. Magleby, Kelli McFarland, Lancaster, Latorre, Lawrence Salkoff, Lee, Lee, Li, Lingle, Long, Marty, Meera, Meera, Meredith, Nimigean, Niu, Orio, Pallotta, Petersen, Robitaille, Rothberg, Schreiber, Shen, Shi, Silberberg, Sun, Sweet, Tao, Tseng-Crank, Wallner, Wei, Wellman, Wu, Wu, Xia, Xia, Xia, Yakang Jin, Yang, Yang, Yang, Yang, Yanyan Geng, Yuan, Yuan, Zhang, Zhang   +74 more
core   +3 more sources

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source

Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus

Frontiers in Cellular Neuroscience, 2019
Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 ...
Jakob J. Gutzmann, Lin Lin, Dax A. Hoffman   +2 more
doaj   +1 more source