Results 131 to 140 of about 434,844 (347)

KTt-45, a T-type calcium channel blocker, acts as an anticancer agent by inducing apoptosis on HeLa cervical cancer cell line. [PDF]

Sci Rep, 2023
Du NH, Ngoc TTB, Cang HQ, Luyen NTT, Thuoc TL, Le Quan T, Thao DTP.   +6 more
europepmc   +1 more source

Minimal alterations in T‐type calcium channel gating markedly modify physiological firing dynamics [PDF]

, 2011
Anne Tscherter, François David, Т. И. Иванова, Charlotte Deleuze, John J. Renger, Victor N. Uebele, H SHIN, Thierry Bal, Nathalie Leresche, Régis C. Lambert   +9 more
openalex   +1 more source

The safety and efficacy of efonidipine, an L- and T-type dual calcium channel blocker, on heart rate and blood pressure in Indian patients with mild-to-moderate essential hypertension

, 2021
Pankaj Jariwala, Kartik Jadhav, Saket Khetan   +2 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

The T-type calcium channel Ca V 3.2 regulates bladder afferent responses to mechanical stimuli. [PDF]

Pain, 2023
Grundy L, Tay C, Christie S, Harrington AM, Castro J, Cardoso FC, Lewis RJ, Zagorodnyuk V, Brierley SM.   +8 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain. [PDF]

Elife, 2022
Fayad SL, Ourties G, Le Gac B, Jouffre B, Lamoine S, Fruquière A, Laffray S, Gasmi L, Cauli B, Mallet C, Bourinet E, Bessaih T, Lambert RC, Leresche N.   +13 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Voltage-Gated T-Type Calcium Channel Modulation by Kinases and Phosphatases: The Old Ones, the New Ones, and the Missing Ones. [PDF]

Cells, 2023
Sharma A, Rahman G, Gorelik J, Bhargava A.   +3 more
europepmc   +1 more source