Results 11 to 20 of about 434,844 (347)
SYNTHESIS OF 1,3,4-OXADIAZOLES AS SELECTIVE T-TYPE CALCIUM CHANNEL INHIBITORS. [PDF]
Heterocycles, 2020 Zhang M +10 more
europepmc +2 more sources
Journal of Pharmacological Sciences, 2019 We tested whether genetic deletion of Cav3.2 T-type Ca2+ channels abolishes hydrogen sulfide (H2S)-mediated pain signals in mice. In Cav3.2-expressing HEK293 cells, Na2S, an H2S donor, at 100 μM clearly increased Ba2+ currents, as assessed by whole-cell ...
Kazuki Matsui +13 more
doaj +2 more sources
T-Type Calcium Channels: A Mixed Blessing
International Journal of Molecular Sciences, 2022 The role of T-type calcium channels is well established in excitable cells, where they preside over action potential generation, automaticity, and firing. They also contribute to intracellular calcium signaling, cell cycle progression, and cell fate; and, in this sense, they emerge as key regulators also in non-excitable cells.
Dario Melgari +5 more
openaire +2 more sources
Pharmaceuticals, 2023 Renin-angiotensin system (RAS) inhibitors and calcium channel blockers (CCB) are often used together in chronic kidney disease (CKD). The PubMed, EMBASE, and Cochrane Library databases were searched to identify randomized controlled trials (RCTs) in ...
Mingming Zhao +9 more
doaj +1 more source
Structure, gating, and pharmacology of human CaV3.3 channel
Nature Communications, 2022 T-type calcium channels are implicated in many diseases. Here, multiple structures of CaV3.3 channel elucidate molecular mechanisms of T-type CaV channels activation at low voltage and interaction with different clinically used channel blockers.
Lingli He +13 more
doaj +1 more source
Verapamil Block of T-Type Calcium Channels [PDF]
Molecular Pharmacology, 2011 Verapamil is a prototypical phenylalkylamine (PAA), and it was the first calcium channel blocker to be used clinically. It tonically blocks L-type channels in the inner pore with micromolar affinity, and its affinity increases at depolarized membrane potentials.
Pamela, Bergson +4 more
openaire +2 more sources
Inactivation of CACNA1H induces cell apoptosis by initiating endoplasmic reticulum stress in glioma
Translational Neuroscience, 2023 Ca2+ channels are abnormally expressed in various tumor cells and are involved in the progression of human glioma. Here, we explored the role of a calcium channel, voltage-dependent, T-type, alpha 1H subunit (CACNA1H), which encodes T-type Ca2+ channel ...
Liu Sheng +3 more
doaj +1 more source
Recent advances in the development of T-type calcium channel blockers for pain intervention. [PDF]
Br J Pharmacol, 2018 Snutch TP, Zamponi GW.
europepmc +3 more sources
T-type calcium channels in neuropathic pain [PDF]
Pain, 2016 Pain is a quite frequent complaint accompanying numerous pathologies. Among these pathological cases, numerous neuropathies are retrieved with identified etiologies (chemotherapies, diabetes, surgeries…) and also more diffuse syndromes such as fibromyalgia. More broadly, pain is one of the first consequences of most inherited diseases.
Bourinet, Emmanuel +2 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2011 .: Transforming growth factor beta-1 (TGF-β1) plays a critical role in progression of cardiac fibrosis, which may involve intracellular calcium change. We examined effects of efonidipine, a dual T-type and L-type calcium channel blocker (CCB), on TGF-β1 ...
Bai Lei +10 more
doaj +1 more source