Results 11 to 20 of about 183,628 (256)

Automated gait analysis indicates efficacy of T-type calcium channel inhibition for mitigation of disrupted calcium signalling in an SCA5 mouse model. [PDF]

Sci Rep
Suminaite D, Talib NF, Pettegree SJ, Tan HCG, Odey YL, Perkins EM, Lyndon AR, Skehel PA, Jackson M.   +8 more
europepmc   +3 more sources

Recent advances in the development of T-type calcium channel blockers for pain intervention. [PDF]

Br J Pharmacol, 2018
Snutch TP, Zamponi GW.
europepmc   +3 more sources

N-/T-Type vs. L-Type Calcium Channel Blocker in Treating Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Pharmaceuticals, 2023
Renin-angiotensin system (RAS) inhibitors and calcium channel blockers (CCB) are often used together in chronic kidney disease (CKD). The PubMed, EMBASE, and Cochrane Library databases were searched to identify randomized controlled trials (RCTs) in ...
Mingming Zhao, Ziyan Zhang, Zhiyu Pan, Sijia Ma, Meiying Chang, Jiao Fan, Shunxuan Xue, Yuejun Wang, Hua Qu, Yu Zhang   +9 more
doaj   +1 more source

Structure, gating, and pharmacology of human CaV3.3 channel

Nature Communications, 2022
T-type calcium channels are implicated in many diseases. Here, multiple structures of CaV3.3 channel elucidate molecular mechanisms of T-type CaV channels activation at low voltage and interaction with different clinically used channel blockers.
Lingli He, Zhuoya Yu, Ze Geng, Zhuo Huang, Changjiang Zhang, Yanli Dong, Yiwei Gao, Yuhang Wang, Qihao Chen, Le Sun, Xinyue Ma, Bo Huang, Xiaoqun Wang, Yan Zhao   +13 more
doaj   +1 more source

Inactivation of CACNA1H induces cell apoptosis by initiating endoplasmic reticulum stress in glioma

Translational Neuroscience, 2023
Ca2+ channels are abnormally expressed in various tumor cells and are involved in the progression of human glioma. Here, we explored the role of a calcium channel, voltage-dependent, T-type, alpha 1H subunit (CACNA1H), which encodes T-type Ca2+ channel ...
Liu Sheng, Ba Ying, Li Chenglong, Xu Guangming   +3 more
doaj   +1 more source

Effect of Efonidipine on TGF-β1–Induced Cardiac Fibrosis Through Smad2-Dependent Pathway in Rat Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2011
.: Transforming growth factor beta-1 (TGF-β1) plays a critical role in progression of cardiac fibrosis, which may involve intracellular calcium change. We examined effects of efonidipine, a dual T-type and L-type calcium channel blocker (CCB), on TGF-β1 ...
Bai Lei, Hirofumi Hitomi, Tatsuhiko Mori, Yukiko Nagai, Kazushi Deguchi, Hirohito Mori, Tsutomu Masaki, Daisuke Nakano, Hiroyuki Kobori, Yasushi Kitaura, Akira Nishiyama   +10 more
doaj   +1 more source

Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons. [PDF]

PLoS ONE, 2014
Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy.
Allison Sargoy, Xiaoping Sun, Steven Barnes, Nicholas C Brecha   +3 more
doaj   +1 more source

Neuroprotective effects of blockers for T-type calcium channels

Molecular Neurodegeneration, 2009
Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin, Baird Michelle A, Lin-Ye Avary, Wildburger Norelle C, Bao Jianxin   +4 more
doaj   +1 more source

Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss

Molecular Brain, 2023
T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes encoding different T-type calcium channels.
Robin N. Stringer, Leos Cmarko, Gerald W. Zamponi, Michel De Waard, Norbert Weiss   +4 more
doaj   +1 more source

T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice

Journal of Pharmacological Sciences, 2018
T-type calcium channels are involved in the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel spiroimidazopyridine compound, SAK3 (ethyl 8′-methyl-2′,4-dioxo-2-(piperidin-1-yl)-2′H-spiro[cyclopentane-1,3′-imidazo[1,2-a]pyridine]
Jing Xu, Yasushi Yabuki, Mengze Yu, Kohji Fukunaga   +3 more
doaj   +1 more source