Results 21 to 30 of about 183,628 (256)

Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide

Molecular Brain, 2020
Low-voltage-activated Cav3 calcium channels (T-type) play an essential role in the functioning of the nervous system where they support oscillatory activities that relie on several channel molecular determinants that shape their unique gating properties.
Leos Cmarko, Norbert Weiss
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Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice

Frontiers in Cellular Neuroscience, 2015
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (α1H T-type) calcium channels; KLHL1 knockdown experiments (KD) cause down-regulation of both channel types and altered synaptic properties
Paula Patricia Perissinotti, Elizabeth G. Ethington, Erik eAlmazan, Elizabeth eMartínez-Hernández, Jennifer eKalil, Michael D. Koob, Erika S. Piedras-Renteria, Erika S. Piedras-Renteria   +7 more
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The role of T-type calcium channel genes in absence seizures

Frontiers in Neurology, 2014
The thalamic relay neurons, reticular thalamic nucleus, and neocortical pyramidal cells form a circuit that sustains oscillatory burst firing, and is regarded as the underlying mechanism of absence seizures.
Yucai eChen, Yucai eChen, William Davis Parker, Keling eWang   +3 more
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NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice

Journal of Pharmacological Sciences, 2019
We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v.
Sachi Matsuda, Hiroyuki Nishikawa, Anna Fukatsu, Yuko Kurokawa, Maho Tsubota, Fumiko Sekiguchi, Shogo Tokuyama, Atsufumi Kawabata   +7 more
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Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin

Frontiers in Neuroscience, 2021
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions.
Paula P. Perissinotti, Elizabeth Martínez-Hernández, Yungui He, Michael D. Koob, Erika S. Piedras-Rentería   +4 more
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Cav3.2-dependent hyperalgesia/allodynia following intrathecal and intraplantar zinc chelator administration in rodents

Journal of Pharmacological Sciences, 2023
Cav3.2, a T-type calcium channel (T-channel) family member, is expressed in the nociceptors and spinal cord, and its activity is largely suppressed by zinc under physiological conditions.
Shiori Tomita, Fumiko Sekiguchi, Katsuki Naoe, Shiyu Shikimi, Yoshihito Kasanami, Maya Ohigashi, Maho Tsubota, Atsufumi Kawabata   +7 more
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T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

Stem Cell Reports, 2018
Summary: Parkinson disease (PD) is a progressive neurological disease caused by selective degeneration of dopaminergic (DA) neurons in the substantia nigra. Although most cases of PD are sporadic cases, familial PD provides a versatile research model for
Yoshikuni Tabata, Yoichi Imaizumi, Michiko Sugawara, Tomoko Andoh-Noda, Satoe Banno, MuhChyi Chai, Takefumi Sone, Kazuto Yamazaki, Masashi Ito, Kappei Tsukahara, Hideyuki Saya, Nobutaka Hattori, Jun Kohyama, Hideyuki Okano   +13 more
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Accumulation of Cav3.2 T-type Calcium Channels in the Uninjured Sural Nerve Contributes to Neuropathic Pain in Rats with Spared Nerve Injury

Frontiers in Molecular Neuroscience, 2018
Injuries to peripheral nerve fibers induce neuropathic pain. But the involvement of adjacent uninjured fibers to pain is not fully understood. The present study aims to investigate the possible contribution of Cav3.2 T-type calcium channels in uninjured ...
Wen Chen, Wen Chen, Wen Chen, Ye-Nan Chi, Ye-Nan Chi, Xue-Jing Kang, Qing-Ying Liu, Hao-Lin Zhang, Zhi-Hua Li, Zi-Fang Zhao, Yin Yang, Li Su, Li Su, Jie Cai, Fei-Fei Liao, Ming Yi, You Wan, You Wan, You Wan, Feng-Yu Liu, Feng-Yu Liu   +20 more
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The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg

Neurobiology of Disease, 2016
Childhood absence epilepsy (CAE) is often comorbid with behavioral and cognitive symptoms, including impaired visual memory. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is an animal model closely resembling CAE; however, cognition in GAERS is ...
Wendie N. Marks, Stuart M. Cain, Terrance P. Snutch, John G. Howland   +3 more
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µ-Theraphotoxin Pn3a inhibition of CaV3.3 channels reveals a novel isoform-selective drug binding site

eLife, 2022
Low voltage-activated calcium currents are mediated by T-type calcium channels CaV3.1, CaV3.2, and CaV3.3, which modulate a variety of physiological processes including sleep, cardiac pace-making, pain, and epilepsy. CaV3 isoforms’ biophysical properties,
Jeffrey R McArthur, Jierong Wen, Andrew Hung, Rocio K Finol-Urdaneta, David J Adams   +4 more
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