Results 21 to 30 of about 434,844 (347)

Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons. [PDF]

PLoS ONE, 2014
Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy.
Allison Sargoy, Xiaoping Sun, Steven Barnes, Nicholas C Brecha   +3 more
doaj   +1 more source

Targetable T-type Calcium Channels Drive Glioblastoma [PDF]

Cancer Research, 2017
Abstract Glioblastoma (GBM) stem-like cells (GSC) promote tumor initiation, progression, and therapeutic resistance. Here, we show how GSCs can be targeted by the FDA-approved drug mibefradil, which inhibits the T-type calcium channel Cav3.2.
Ying, Zhang, Nichola, Cruickshanks, Fang, Yuan, Baomin, Wang, Mary, Pahuski, Julia, Wulfkuhle, Isela, Gallagher, Alexander F, Koeppel, Sarah, Hatef, Christopher, Papanicolas, Jeongwu, Lee, Eli E, Bar, David, Schiff, Stephen D, Turner, Emanuel F, Petricoin, Lloyd S, Gray, Roger, Abounader   +16 more
openaire   +2 more sources

Neuroprotective effects of blockers for T-type calcium channels

Molecular Neurodegeneration, 2009
Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin, Baird Michelle A, Lin-Ye Avary, Wildburger Norelle C, Bao Jianxin   +4 more
doaj   +1 more source

Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide

Molecular Brain, 2020
Low-voltage-activated Cav3 calcium channels (T-type) play an essential role in the functioning of the nervous system where they support oscillatory activities that relie on several channel molecular determinants that shape their unique gating properties.
Leos Cmarko, Norbert Weiss
doaj   +1 more source

Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss

Molecular Brain, 2023
T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes encoding different T-type calcium channels.
Robin N. Stringer, Leos Cmarko, Gerald W. Zamponi, Michel De Waard, Norbert Weiss   +4 more
doaj   +1 more source

Functional Importance of L- and P/Q-Type Voltage-Gated Calcium Channels in Human Renal Vasculature [PDF]

, 2011
Calcium channel blockers are widely used for treatment of hypertension, because they decrease peripheral vascular resistance through inhibition of voltage-gated calcium channels.
Cribbs, Leanne L, Hansen, Pernille B, Jensen, Boye L, Marcussen, Niels, Poulsen, Christian B, Skøtt, Ole, Walter, Steen   +6 more
core   +1 more source

T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice

Journal of Pharmacological Sciences, 2018
T-type calcium channels are involved in the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel spiroimidazopyridine compound, SAK3 (ethyl 8′-methyl-2′,4-dioxo-2-(piperidin-1-yl)-2′H-spiro[cyclopentane-1,3′-imidazo[1,2-a]pyridine]
Jing Xu, Yasushi Yabuki, Mengze Yu, Kohji Fukunaga   +3 more
doaj   +1 more source

Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice

Frontiers in Cellular Neuroscience, 2015
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (α1H T-type) calcium channels; KLHL1 knockdown experiments (KD) cause down-regulation of both channel types and altered synaptic properties
Paula Patricia Perissinotti, Elizabeth G. Ethington, Erik eAlmazan, Elizabeth eMartínez-Hernández, Jennifer eKalil, Michael D. Koob, Erika S. Piedras-Renteria, Erika S. Piedras-Renteria   +7 more
doaj   +1 more source

Mechanisms of lateral inhibition in the olfactory bulb: Efficiency and modulation of spike-evoked calcium influx into granule cells [PDF]

, 2003
Granule cells are axonless local interneurons that mediate lateral inhibitory interactions between the principal neurons of the olfactory bulb via dendrodendritic reciprocal synapses.
Egger, V., Mainen, Z. F., Svoboda, K.
core   +1 more source

A T-type channel-calmodulin complex triggers αCaMKII activation [PDF]

, 2017
Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity.
Asmara, Hadhimulya, Engbers, Jordan D. T., Micu, Ileana, Rizwan,, Arsalan P., Sahu, Giriraj, Simms,, Brett A., Stys, Peter K., Turner, Ray W., Zamponi, Gerald W., Zhang, Fang-Xiong   +9 more
core   +2 more sources