Results 311 to 320 of about 434,844 (347)

T-type calcium channels in differentiation and proliferation

Cell Calcium, 2006
Low-voltage activated, T-type calcium channels (T-channels) are expressed in many developing tissues and may be important in regulating important cellular phenotype transitions leading to cell proliferation, differentiation, growth and death. The purpose of this review is to relate and delineate the current data on the involvement of T-channels in ...
Philippe, Lory, Isabelle, Bidaud, Jean, Chemin   +2 more
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Molecular characterization of T-type calcium channels

Cell Calcium, 2006
Molecular cloning of the low voltage-gated, T-type, calcium channel family opened new avenues of research into their structure-function, distribution, pharmacology, and regulation. Cloning of mammalian cDNAs led to the identification of three T-channel genes: CACNA1G, encoding Cav3.1; CACNA1H, encoding Cav3.2; and CACNA1I, encoding Cav3.3. This allowed
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Temperature dependence of T-type calcium channel gating

Neuroscience, 2006
T-type calcium channel isoforms are expressed in a multitude of tissues and have a key role in a variety of physiological processes. To fully appreciate the physiological role of distinct channel isoforms it is essential to determine their kinetic properties under physiologically relevant conditions.
M, Iftinca, B E, McKay, T P, Snutch, J E, McRory, R W, Turner, G W, Zamponi   +5 more
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T-type calcium channels inhibitors: a patent review

Expert Opinion on Therapeutic Patents, 2010
T-type calcium channels are transmembrane proteins that regulate calcium entry in the cell in a voltage-dependent manner. Intracellular calcium levels are the key to many physiological processes, ranging from neuron firing to cardiac pacemaking. Inhibition of T-type calcium channels is heralded as a potential treatment to peripheral and CNS disorders ...
Fabrizio, Giordanetto, Laurent, Knerr, Andreas, Wållberg   +2 more
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T-Type Calcium Channels and Epilepsy

2013
Epilepsy is characterized by spontaneous recurrent seizures in which electrical activity in particular brain regions becomes over-excitable. As different brain regions interact in cycle, one excites the next until they become locked into a self-propagating loop.
Stuart M. Cain, Michael E. Hildebrand, Terrance P. Snutch   +2 more
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Sodium/calcium selectivity of cloned calcium T-type channels

Neurophysiology, 2006
We studied the peculiarities of permeability with respect to the main extracellular cations, Na+ and Ca2+, of cloned low-threshold calcium channels (LTCCs) of three subtypes, Cav3.1 (α1G), Cav3.2 (α 1H), and Cav3.3 (α1I), functionally expressed in Xenopus oocytes.
A. K. Shcheglovitov, Ya. M. Shuba
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T-type calcium channel in mammalian CNS neurones

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1991
1. In all neurones freshly isolated from various brain regions of newborn, adult and aged rats, the T-type Ca2+ currents were elicited by step depolarizations to potentials more positive than -60 mV from a holding potential of -100 mV, and reached a peak in the current-voltage relationship around -30 mV. 2.
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Dehydroepiandrosterone (DHEA) inhibits voltage-gated T-type calcium channels

Biochemical Pharmacology, 2012
Dehydroepiandrosterone (DHEA) and its sulfated form, DHEAS, are the most abundant steroid hormones in the mammalian blood flow. DHEA may have beneficial effects in various pathophysiological conditions such as cardiovascular diseases or deterioration of the sense of well-being.
Chevalier, M., Gilbert, Guillaume, Lory, P., Marthan, R., Quignard, J.F., Savineau, J.P.   +5 more
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Models of calcium permeation through T-type channels

Pflügers Archiv - European Journal of Physiology, 2014
Ca(2+) entry is indispensable part of intracellular Ca(2+) signaling, which is vital for most of cellular functions. Low voltage-activated (LVA or T-type) calcium channels belong to the family of voltage-gated calcium channels (VGCCs) which provide Ca(2+) entry in response to membrane depolarization.
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First pharmacophoric hypothesis for T-type calcium channel blockers

Bioorganic & Medicinal Chemistry, 2004
A three-dimensional pharmacophore model was developed for T-type calcium channel blockers in order to map common structural features of highly active compounds by using CATALYST program. In the absence of three dimensional structure based information like binding mode and unavailability of more number of specific T-type calcium channel blockers, this ...
Munikumar Reddy, Doddareddy, Hee Kyung, Jung, Jae Yeol, Lee, Yong Sup, Lee, Yong Seo, Cho, Hun Yeong, Koh, Ae Nim, Pae   +6 more
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