Results 31 to 40 of about 434,844 (347)

Role of T-type calcium channels in myogenic tone of skeletal muscle resistance arteries [PDF]

, 2002
T-type calcium channels may be involved in the maintenance of myogenic tone. We tested their role in isolated rat cremaster arterioles obtained after CO2 anesthesia and decapitation.
Andreasen, Ditte, Jensen, Boye L, Pfaffendorf, Martin, Sorop, Oana, VanBavel, Ed   +4 more
core   +2 more sources

NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice

Journal of Pharmacological Sciences, 2019
We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v.
Sachi Matsuda, Hiroyuki Nishikawa, Anna Fukatsu, Yuko Kurokawa, Maho Tsubota, Fumiko Sekiguchi, Shogo Tokuyama, Atsufumi Kawabata   +7 more
doaj   +1 more source

A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity [PDF]

, 2016
CACNA1I is a candidate schizophrenia risk gene. It encodes the pore-forming human CaV3.3 α1 subunit, a subtype of voltage-gated calcium channel that contributes to T-type currents.
Allen, Alexander, Andrade, A., Hope, Jennifer M., Lipscombe, D., Pan, Jennifer Q., Yorgan, Valerie A   +5 more
core   +1 more source

Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin

Frontiers in Neuroscience, 2021
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions.
Paula P. Perissinotti, Elizabeth Martínez-Hernández, Yungui He, Michael D. Koob, Erika S. Piedras-Rentería   +4 more
doaj   +1 more source

TRPV6 modulates proliferation of human pancreatic neuroendocrine BON-1 tumour cells [PDF]

, 2016
Highly Ca2+ permeable receptor potential channel vanilloid type 6 (TRPV6) modulates a variety of biological functions including calcium-dependent cell growth and apoptosis.
Khajavi, Noushafarin, Kolodziejski, Pawel A., Mergler, Stefan, Nowak, Krzysztof W., Skrzypski, Marek, Strowski, Mathias Z., Strowski, Mathias Z.   +6 more
core   +1 more source

The many faces of T-type calcium channels [PDF]

Pflügers Archiv - European Journal of Physiology, 2013
Since the discovery of low-voltage-activated T-type calcium channels in sensory neurons and the initial characterization of their physiological function mainly in inferior olive and thalamic neurons, studies on neuronal T-type currents have predominantly focused on the generation of low-threshold spike (and associated action potential burst firing ...
Lambert, R.C., Bessaïh, Thomas, Crunelli, Vincenzo, Leresche, Nathalie   +3 more
openaire   +3 more sources

Cav3.2-dependent hyperalgesia/allodynia following intrathecal and intraplantar zinc chelator administration in rodents

Journal of Pharmacological Sciences, 2023
Cav3.2, a T-type calcium channel (T-channel) family member, is expressed in the nociceptors and spinal cord, and its activity is largely suppressed by zinc under physiological conditions.
Shiori Tomita, Fumiko Sekiguchi, Katsuki Naoe, Shiyu Shikimi, Yoshihito Kasanami, Maya Ohigashi, Maho Tsubota, Atsufumi Kawabata   +7 more
doaj   +1 more source

T-type calcium channel blockers as neuroprotective agents [PDF]

Pflügers Archiv - European Journal of Physiology, 2014
T-type calcium channels are expressed in many diverse tissues, including neuronal, cardiovascular, and endocrine. T-type calcium channels are known to play roles in the development, maintenance, and repair of these tissues but have also been implicated in disease when not properly regulated. Calcium channel blockers have been developed to treat various
Benjamin J, Kopecky, Ruqiang, Liang, Jianxin, Bao   +2 more
openaire   +2 more sources

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

Stem Cell Reports, 2018
Summary: Parkinson disease (PD) is a progressive neurological disease caused by selective degeneration of dopaminergic (DA) neurons in the substantia nigra. Although most cases of PD are sporadic cases, familial PD provides a versatile research model for
Yoshikuni Tabata, Yoichi Imaizumi, Michiko Sugawara, Tomoko Andoh-Noda, Satoe Banno, MuhChyi Chai, Takefumi Sone, Kazuto Yamazaki, Masashi Ito, Kappei Tsukahara, Hideyuki Saya, Nobutaka Hattori, Jun Kohyama, Hideyuki Okano   +13 more
doaj   +1 more source