Results 41 to 50 of about 434,844 (347)

Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium [PDF]

Rises in intracellular calcium are essential for contraction of human myometrial smooth muscle (HMSM) and hence parturition. The T-type calcium channel may play a role in this process.
Anwer, Astle, Challis, Cribbs, Eller, Fry, Garfield, Gomora, Jones, Khan, Khan, Kim, Klockner, Knock, Knock, Lee, Lee, Monteil, Moosmang, Nebe, Ohkubo, Ohkubo, Parkington, Parkington, Perez, Perez-Reyes, Perez-Reyes, Perez-Reyes, Viana, Woodcock, Young, Young, Zamponi   +32 more
core   +2 more sources

The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg

Neurobiology of Disease, 2016
Childhood absence epilepsy (CAE) is often comorbid with behavioral and cognitive symptoms, including impaired visual memory. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is an animal model closely resembling CAE; however, cognition in GAERS is ...
Wendie N. Marks, Stuart M. Cain, Terrance P. Snutch, John G. Howland   +3 more
doaj   +1 more source

µ-Theraphotoxin Pn3a inhibition of CaV3.3 channels reveals a novel isoform-selective drug binding site

eLife, 2022
Low voltage-activated calcium currents are mediated by T-type calcium channels CaV3.1, CaV3.2, and CaV3.3, which modulate a variety of physiological processes including sleep, cardiac pace-making, pain, and epilepsy. CaV3 isoforms’ biophysical properties,
Jeffrey R McArthur, Jierong Wen, Andrew Hung, Rocio K Finol-Urdaneta, David J Adams   +4 more
doaj   +1 more source

Accumulation of Cav3.2 T-type Calcium Channels in the Uninjured Sural Nerve Contributes to Neuropathic Pain in Rats with Spared Nerve Injury

Frontiers in Molecular Neuroscience, 2018
Injuries to peripheral nerve fibers induce neuropathic pain. But the involvement of adjacent uninjured fibers to pain is not fully understood. The present study aims to investigate the possible contribution of Cav3.2 T-type calcium channels in uninjured ...
Wen Chen, Wen Chen, Wen Chen, Ye-Nan Chi, Ye-Nan Chi, Xue-Jing Kang, Qing-Ying Liu, Hao-Lin Zhang, Zhi-Hua Li, Zi-Fang Zhao, Yin Yang, Li Su, Li Su, Jie Cai, Fei-Fei Liao, Ming Yi, You Wan, You Wan, You Wan, Feng-Yu Liu, Feng-Yu Liu   +20 more
doaj   +1 more source

Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade [PDF]

, 2003
<b>1.</b> 5-Hydroxytryptamine (5-HT) has been postulated to play a proarrhythmic role in the human atria via stimulation of 5-HT₄ receptors.
Andrew C Rankin, Antony J Workman, BERS, BLONDEL, Davide Pau, DAWODU, GRAMMER, GRIMM, HALL, HEGDE, JAHNEL, JAHNEL, JIA, JOSEPH, KAMATH, Kathleen A Kane, KAUMANN, KAUMANN, KAUMANN, LEVY, MEDHURST, MOE, NATTEL, NEHER, OUADID, RAHME, SANDERS, TONINI, WANG, WANGEMANN, WORKMAN, WORKMAN, YUE   +32 more
core   +2 more sources

The role of inhibitory G proteins and regulators of G protein signaling in the in vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]

, 2012
Inhibitory heterotrimeric G proteins and the control of heart rate. The activation of cell signaling pathways involving inhibitory heterotrimeric G proteins acts to slow the heart rate via modulation of ion channels.
Ang, R, Opel, A, Tinker, A
core   +1 more source

Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse [PDF]

, 2019
In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the CNS. During postnatal development, however, medial olivocochlear (MOC) efferent fibers transiently innervate the IHCs ...
Elgoyhen, Ana Belen, Katz, Eleonora, Kearney, Graciela Inés, Vattino, Lucas Gabriel, Wedemeyer, Carolina, Zorrilla de San Martín, Javier   +5 more
core   +1 more source

The prostaglandin E2/EP4 receptor/cyclic AMP/T-type Ca2+ channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells

Journal of Pharmacological Sciences, 2016
We investigated mechanisms for the neuritogenesis caused by prostaglandin E2 (PGE2) or intracellular cyclic AMP (cAMP) in sensory neuron-like ND7/23 cells.
Kenji Mitani, Fumiko Sekiguchi, Takashi Maeda, Yukari Tanaka, Shigeru Yoshida, Atsufumi Kawabata   +5 more
doaj   +1 more source

The Roles of Calcium Ions in Parkinson’s Disease: Calcium Channel Inhibitors as a Novel Agents?

Journal of Molecular Pathology, 2022
Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons, which results in motor impairment.
Md Reyaz Alam, Khadga Raj, Shamsher Singh   +2 more
doaj   +1 more source

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source