Results 91 to 100 of about 1,773,732 (261)

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

Cardiovascular Manifestations of Patients with Long COVID

open access: yesDiagnostics
Background: This study investigates the potential mechanisms behind changes in cardiac structure and function in long COVID patients. Methods: This study involved 176 consecutive outpatients in follow-up care (average age 55.9 years; 58.5% male) who ...
Gordana Krljanac   +13 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

Evidence of electron neutrino appearance in a muon neutrino beam [PDF]

open access: yes, 2013
The T2K collaboration reports evidence for electron neutrino appearance at the atmospheric mass splitting, |\Delta m_{32}^2|=2.4x10^{-3} eV^2. An excess of electron neutrino interactions over background is observed from a muon neutrino beam with a peak ...
A. Ereditato   +999 more
core   +2 more sources

The Effectiveness of Digital vs. Analogue Teaching Resources in a Flipped Classroom for Undergraduate Focus Cardiac Ultrasound Training: A Prospective, Randomised, Controlled Single-Centre Study

open access: yesEducation Sciences
Introduction: This study investigated the effectiveness of e-learning compared to traditional teaching methods in ultrasound education, centring on a focus cardiac ultrasound (FoCUS) course for third-year undergraduate medical students.
Johannes Weimer   +12 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

Study of neutrino-induced neutral current neutral pion production in the T2K near detector [PDF]

open access: yes, 2013
The T2K experiment is a long baseline neutrino oscillation experiment. The most intense accelerator muon neutrino beam ever built is produced at the J-PARC facility in Tokai, located on the east coast of Japan, and directed (2.5 [degrees] off -axis ...
Short, Samantha
core   +1 more source

Metabolomic Alterations in Patients with Obesity and the Impact of Metabolic Bariatric Surgery: Insights for Future Research

open access: yesMetabolites
Metabolomics has emerged as a vital tool for understanding the body’s responses to therapeutic interventions. Metabolic bariatric surgery (MBS) is widely recognized as the most effective treatment modality for severe obesity and its associated ...
Ioanna A. Anastasiou   +8 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

open access: yesFEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav   +4 more
wiley   +1 more source

Constraint on the matter–antimatter symmetry-violating phase in neutrino oscillations [PDF]

open access: yes, 2019
The current laws of physics do not explain the observed imbalance of matter and antimatter in the universe. Sakharov proposed that an explanation would require the violation of CP symmetry between matter and antimatter.
Morrison J.   +999 more
core   +2 more sources

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