Results 71 to 80 of about 1,773,732 (261)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Influência da baixa salinidade na sobrevivência de náuplios de Artemia sp.

Boletim do Instituto de Pesca, 2018
O objetivo do trabalho foi avaliar a sobrevivência de náuplios de Artemia sp. submetidos a diferentes concentrações salinas. Testaram-se quatro tratamentos em triplicata, distribuí­­dos em delineamento inteiramente ao acaso - T1: 0‰; T2: 1,7ââ ...
Luis Fernando Beux, Evoy Zaniboni Filho
doaj  

Effects of Coping, Affirmation, Resilience, and Empowerment (CARE)Program on Depression, Mental Health Literacy, and Coping Skills among People with Depression in Indonesia: A Mixed Methods Study

Asian Journal of Social Health and Behavior
Introduction: Coping, affirmation, resilience, and empowerment (CARE) program was designed to support patients with depression. We combined psychoeducation and coping skills to help people with depression cope with depressive symptoms and stressful life ...
Lafi Munira, Pranee Liamputtong, Pramon Viwattanakulvanid   +2 more
doaj   +1 more source

Effect of dietary yeast and oligosaccharide on growth performances of broiler

Journal of Agriculture, Food and Environment, 2020
This study was conducted to evaluate the effect of feeding graded levels of yeast (Saccharomyces cerevisiae) and oligosaccharide on broiler performance.
M. M. U. Patoary
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Zinc methionine supplementation during the summer season enhanced the growth, immunity, antioxidants and zinc retention of broiler chickens

Indian Journal of Animal Sciences
The current study is aimed for determining the optimal dose of zinc methionine (Zn-met) in broiler birds during the summer season in order to improve growth, immunity, stress tolerance, and concentration of Zn in vital organs. Total of 240 number of one
U S MISHRA, K SETHY, N PANDA, S K MISHRA, K BEHERA, V T ANDHALE, D THAKUR   +6 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Microbiological dynamics of different poultry waste disposal methods

Indian Journal of Animal Sciences
The improper handling and disposal of animal excrement, especially that from chickens and other animals, has historically resulted in serious environmental and societal difficulties.
GURPREET KAUR, DALJEET KAUR, PAVITER KAUR, NEEMISHA, SANDEEP UNIYAL, YASHPAL SINGH, D S MALIK   +6 more
doaj   +1 more source

Frequency of occurrence of type 2 diabetes and metabolic disturbances in patients with schizophrenic range disorders with prolonged anti-relapse antipsychotic therapy (based on screening results)

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
The article presents the results of screening data from a simultaneous study of 443 outpatient cards of patients with schizophrenic spectrum disorders who were under dynamic outpatient monitoring in two areas of the psycho-neurological dispensary No.
L. N. Gorobets, M. A. Tsarenko, A. V. Litvinov, L. M. Vasilenko   +3 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source