Results 101 to 110 of about 154,795 (245)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao +7 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Hemodialysis (HD) patients are at higher risk of severe COVID‐19 and may exhibit suboptimal vaccine responses. This study evaluates the factors influencing vaccine‐induced immunity in HD patients following the second dose of the Vaxzevria. A total of 276 HD patients and 126 controls were included. Antibody responses were assessed using binding
Chia‐Wei Chang +9 more
wiley +1 more source
Lipids, EarlyView.ABSTRACT Although sphingolipids are key players in lipotoxicity and metabolic diseases, their response to bariatric surgery and their relation to metabolic improvement remain unclear. This pilot study investigated plasma sphingolipid remodeling after Roux‐en‐Y gastric bypass (RYGB) and its associations with clinical and biochemical markers of ...
Gabriela de Oliveira Lemos +3 more
wiley +1 more source
Obesity, EarlyView.ABSTRACT Objective This study compared the efficacy of metabolic/bariatric surgery (MBS) and GLP‐1 receptor agonists (GLP‐1 RAs), including dual GLP‐1/GIP analogues, for weight and metabolic outcomes in adults with obesity. Methods A network meta‐analysis of randomized controlled trials compared MBS or GLP‐1 RAs versus lifestyle intervention in adults ...
Lucas Sabatella +9 more
wiley +1 more source
Obesity, EarlyView.ABSTRACT Objective We previously identified distinct muscle and liver insulin resistance (IR) metabotypes in middle‐aged and older adults. The PERSON study showed that a low‐fat, high‐protein, high‐fiber diet benefits the muscle IR group, while a high‐monounsaturated fatty acid diet benefits the liver IR group. We also developed the MetaboHealth score,
Jordi Morwani‐Mangnani +10 more
wiley +1 more source
Obesity, EarlyView.ABSTRACT Objective Obesity, or excessive body fat, is a significant health risk factor. Western diets (WD) contribute to metabolic dysfunction and obesity, while Mediterranean diets (MD) improve metabolic health. This study examined the contrasting effects of WD versus MD on visceral and subcutaneous adipose tissues (VAT, SAT) using a randomized ...
Aya Jamal Abusheikha +6 more
wiley +1 more source
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To investigate the association of frailty with post‐cochlear implant (CI) admission, morbidity, and CI‐aided word recognition outcomes in veterans. Study Design Retrospective cohort. Setting Single‐institution tertiary care Veterans Health Administration (VHA) hospital.
Kaitlyn A. Brooks +4 more
wiley +1 more source
Pediatric Investigation, EarlyView.Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil +2 more
wiley +1 more source
Portal Hypertension &Cirrhosis, EarlyView.In a retrospective cohort of 236 patients with type 2 diabetes (T2DM), metabolic dysfunction‐associated steatotic liver disease (MASLD) was common and significant fibrosis (liver stiffness measurement [LSM] ≥8 kPa) was frequently observed. Serum chitinase‐3‐like protein 1 (CHI3L1) correlated with LSM (r = 0.48) and remained an independent predictor of ...
Lixia Sun +8 more
wiley +1 more source