Results 91 to 100 of about 30,445,587 (352)

Memory T Cells

Biology of Blood and Marrow Transplantation, 2008
Memory. is the diary that we all carry about with us. Oscar Wilde, ‘‘The Importance of Being Earnest’’ And so it is with the immune system. Memory T cells are a critical component of the adaptive immune system. Our ability to respond rapidly to antigens/ pathogens that we have been exposed to previously is at the heart of the adaptive immune system. In
openaire   +2 more sources

MAVS Is essential for primary CD4 + T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection [PDF]

, 2017
The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development.
Barrett, Alan D, Diamond, Michael S, Fang, Rong, Gale, Michael, Jr, Lazear, Helen M, Li, Li, Luo, Huanle, Paessler, Slobodan, Peng, Bi-Hung, Wang, Tian, Winkelmann, Evandro, Xie, Guorui   +11 more
core   +3 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Simultaneous optical recording of action potentials and calcium transients in cardiac single cells differentiated from type 1 CPVT-iPS cells

Frontiers in Physiology
Numerous reports investigating channelopathies, including Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), have successfully reproduced using cardiomyocytes (CMs) differentiated from human induced pluripotent stem cells (hiPSCs).
Tadashi Takaki, Tadashi Takaki, Tadashi Takaki, Norihisa Tamura, Norihisa Tamura, Kenichi Imahashi, Kenichi Imahashi, Tomoyuki Nishimoto, Tomoyuki Nishimoto, Yoshinori Yoshida, Yoshinori Yoshida   +10 more
doaj   +1 more source

A cell atlas of human thymic development defines T cell repertoire formation

Science, 2020
Thymus development, cell by cell The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection.
Jong-Eun Park, R. Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu, M. Lavaert, Daniel J. Kunz, Issac Goh, Emily Stephenson, Roberta Ragazzini, E. Tuck, A. Wilbrey-Clark, Kenny Roberts, Veronika R. Kedlian, J. Ferdinand, Xiaoling He, S. Webb, Daniel Maunder, N. Vandamme, Krishnaa T. A. Mahbubani, K. Polański, L. Mamanova, L. Bolt, D. Crossland, F. de Rita, A. Fuller, A. Filby, G. Reynolds, D. Dixon, K. Saeb‐Parsy, S. Lisgo, D. Henderson, R. Vento-Tormo, O. Bayraktar, R. Barker, K. Meyer, Y. Saeys, P. Bonfanti, S. Behjati, M. Clatworthy, T. Taghon, M. Haniffa, S. Teichmann   +41 more
semanticscholar   +1 more source

CAR-T Cell Therapy for T-Cell Malignancies.

Mediterranean journal of hematology and infectious diseases
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of B-cell lymphoid neoplasia and, in some instances, improved disease outcomes. Thus, six FDA-approved commercial CAR-T cell products that target antigens preferentially expressed on malignant B-cells or plasma cells have been introduced in the therapy of B-cell lymphomas,
Ugo Testa, Patrizia Chiusolo, Elvira Pelosi, Germana Castelli, Giuseppe Leone   +4 more
openaire   +3 more sources

Early signaling defects in human T cells anergized by T cell presentation of autoantigen. [PDF]

, 1992
Major histocompatibility complex class II-positive human T cell clones are nontraditional antigen-presenting cells (APCs) that are able to simultaneously present and respond to peptide or degraded antigen, but are unable to process intact protein ...
Freeman, GJ, Hafler, DA, LaSalle, JM, Nadler, LM, Tolentino, PJ   +4 more
core  

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner [PDF]

, 2019
MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-kappa B and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions.
Baens, Mathijs, Beyaert, Rudi, Demeyer, Annelies, Driege, Yasmine, Hochepied, Tino, Kreike, Marja, Skordos, Ioannis, Staal, Jens   +7 more
core   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

The Impact of Obesity on the Outcomes of Adult Patients with Acute Lymphoblastic Leukemia – A Single Center Retrospective Study

Blood and Lymphatic Cancer: Targets and Therapy, 2021
Qiuju Liu,1 Brittny Major,2 Jennifer Le-Rademacher,2 Aref A Al-Kali,3 Hassan Alkhateeb,3 Kebede Begna,3 Michelle A Elliott,3 Naseema Gangat,3 William J Hogan,3 C Christopher Hook,3 Scott H Kaufmann,3 Animesh Pardanani,3 Mrinal S Patnaik,3 Ayalew Tefferi ...
Liu Q, Major B, Le-Rademacher J, Al-Kali AA, Alkhateeb H, Begna K, Elliott MA, Gangat N, Hogan WJ, Hook CC, Kaufmann SH, Pardanani A, Patnaik MS, Tefferi A, Wolanskyj-Spinner AP, Wei W, Litzow MR   +16 more
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