Results 121 to 130 of about 8,441,406 (356)

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Illuminating T cell-dendritic cell interactions in vivo by FlAsHing antigens

eLife
Delineating the complex network of interactions between antigen-specific T cells and antigen presenting cells (APCs) is crucial for effective precision therapies against cancer, chronic infections, and autoimmunity.
Munir Akkaya, Jafar Al Souz, Daniel Williams, Rahul Kamdar, Olena Kamenyeva, Juraj Kabat, Ethan Shevach, Billur Akkaya   +7 more
doaj   +1 more source

Not All Immune Checkpoints Are Created Equal

Frontiers in Immunology, 2018
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets in ...
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +3 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

COMPARATIVE-EVALUATION-OF-TWO-VIABILITY ASSAYS ON BIODEGRADABLE POLYMER FOAMS FOR POTENTIAL BONE REGENERATION

Romanian Journal of Medical and Dental Education, 2014
The purpose of the present study was to evaluate comparatively the cytotoxicity of two foams prepared by phosphorylated cellulose and phosphorylated PVA using two common assays, MTT classic assay and Cell-titer blue assay.
Ana Maria Holicov, Tudor Petreuș, Carmen Elena Cotrutz   +2 more
doaj  

T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response

Human Vaccines & Immunotherapeutics, 2018
The delayed availability of vaccine during the 2009 H1N1 influenza pandemic created a sense of urgency to better prepare for the next influenza pandemic.
Leonard Moise, Bethany M. Biron, Christine M. Boyle, Nese Kurt Yilmaz, Hyesun Jang, Celia Schiffer, Ted M. Ross, William D. Martin, Anne S. De Groot   +8 more
doaj   +1 more source

In Vitro Cultivation of Malignant Lymphoblasts of Transplantable Mouse Lymphosarcoma MB (T 86157) without Typical Mesenchyme Cells [PDF]

, 1949
Willemina M. de Bruyn
openalex   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

CORELATIONS BETWEEN THE CLINICAL AND MORFOLOGICAL ASPECTS AND THE MOLECULAR MARKERS IN THE MALIGNANT TRANSFORMATION OF THE ORAL LEUKOPLAKIAS

Romanian Journal of Oral Rehabilitation, 2016
The leukoplakia injuries represent the most frequent premalignant oral injuries. Their clinical and histopathological features are not always significant for the malignant transformation and, implicitly, for their diagnosis.
Doinița Olinici, Laura Gheucă-Solovăstru, Tatiana Țăranu, L. Bădescu, Laura Stoica, Emanuela Ana Botez, Carmen Elena Cotrutz   +6 more
doaj  

Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury

Journal of Inflammation Research, 2022
Qi-Ming Pang,1,2 Si-Yu Chen,1 Sheng-Ping Fu,1,2 Hui Zhou,3 Qian Zhang,4 Jun Ao,2 Xiao-Ping Luo,1 Tao Zhang1,2 1Key Laboratory of Cell Engineering of Guizhou Province and Regenerative Medicine Centre, Affiliated Hospital of Zunyi Medical University, Zunyi,
Pang QM, Chen SY, Fu SP, Zhou H, Zhang Q, Ao J, Luo XP, Zhang T   +7 more
doaj