Results 151 to 160 of about 28,819,884 (406)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing [PDF]

, 2017
Ji Li, Nicola J. Stagg, Jennifer Johnston, Michael J. Harris, Sam A. Menzies, Danielle DiCara, Vanessa Clark, Maria Hristopoulos, Ryan Cook, Dionysos Slaga, Rin Nakamura, McCarty Luke, Siddharth Sukumaran, Elizabeth Luis, Zhengmao Ye, Thomas D. Wu, Teiko Sumiyoshi, Dimitry M. Danilenko, Genee Y. Lee, Klára Tótpál, Diego Ellerman, Isidro Hötzel, John R. James, Teemu T. Junttila   +23 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

PD‐L1 co‐stimulation contributes to ligand‐induced T cell receptor down‐modulation on CD8 ⁺ T cells [PDF]

, 2011
Katarzyna Karwacz, Christopher Bricogne, Douglas MacDonald, Frederick Arce, Clare L. Bennett, Mary S. Collins, David Escors   +6 more
openalex   +1 more source

CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14 [PDF]

, 2020
Bruce K. Patterson, Harish Seethamraju, Kush Dhody, Michael J. Corley, Kazem Kazempour, Jay Lalezari, Alina P.S. Pang, Christopher Sugai, Eisa Mahyari, Edgar B. Francisco, Amruta Pise, Hallison Rodrigues, Helen L. Wu, Gabriela M. Webb, Byung Park, Scott A. Kelly, Nader Pourhassan, Alina Lelic, Lama Kdouh, Mónica Herrera, Eric W. Hall, Benjamin N. Bimber, Matthew Plassmeyer, Raavi Gupta, Oral Alpan, Jane A. O’Halloran, Philip A. Mudd, Enver Akalin, Lishomwa C. Ndhlovu, Jonah B. Sacha   +29 more
openalex   +1 more source

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

Nature, 2020
N. Le Bert, A. Tan, Kamini Kunasegaran, C. Tham, Morteza Hafezi, A. Chia, M. Chng, Meiyin Lin, N. Tan, M. Linster, W. Chia, M. Chen, Lin‐Fa Wang, E. Ooi, S. Kalimuddin, P. Tambyah, J. Low, Yee-Joo Tan, A. Bertoletti   +18 more
semanticscholar   +1 more source

A cell is a cell is a cell

, 2008
Es wurden Erklärverhalten und Einschätzung von Laienwissen durch Experten für die medizinische Emailberatung untersucht. Hierbei wurden die Tutoringforschung sowie psycholinguistische Ansätze berücksichtigt. Eingangs wurde das Wissen einer Laienstichprobe (Studie I, n = 100) per Fragebogen untersucht.
openaire  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The effect of antigen dose on T cell-targeting vaccine outcome

Human Vaccines & Immunotherapeutics, 2019
During the past 3–4 decades, an increasing amount of evidence has pointed to the complex role of the antigen dose or T cell receptor (TCR) stimulation strength on the subsequent type, duration and “flavor” or quality of the response.
Rolf Billeskov, Babak Beikzadeh, Jay A. Berzofsky   +2 more
doaj   +1 more source

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Cell, 2020
T. Sekine, André Perez-Potti, Olga Rivera-Ballesteros, K. Strålin, J. Gorin, Annika Olsson, S. Llewellyn-Lacey, Habiba Kamal, G. Bogdanovic, S. Muschiol, David Wullimann, Tobias Kammann, Johanna E. M. Emgård, Tiphaine Parrot, E. Folkesson, O. Rooyackers, L. Eriksson, A. Sönnerborg, T. Allander, J. Albert, M. Nielsen, J. Klingström, Sara Gredmark-Russ, N. Björkström, J. Sandberg, D. Price, H. Ljunggren, S. Aleman, M. Buggert   +28 more
semanticscholar   +1 more source