Results 151 to 160 of about 8,713,756 (356)

Strategy of Targeted T Cell Immunotherapy for Acute Myeloid Leukemia

Zhongliu Fangzhi Yanjiu
T cell dysfunction is a common feature in patients with acute myeloid leukemia (AML). The up-regulation of immune checkpoint (IC) proteins resulting in T cell exhaustion is a key reason for T cell dysfunction.
LI Yangqiu
doaj   +1 more source

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

, 2021
Nathan Singh, Noelle V. Frey, Boris Engels, David M. Barrett, Olga Shestova, Pranali Ravikumar, Katherine D. Cummins, Yong Gu Lee, Raymone Pajarillo, Inkook Chun, Amy Shyu, Steven L. Highfill, Andrew Price, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xueqing Maggie Lu, David A. Christian, Jessica Perazzelli, Simon F. Lacey, Nathan H. Roy, Janis K. Burkhardt, Florent Colomb, Mohammad Damra, Mohamed Abdel‐Mohsen, Ting Liu, Dongfang Liu, Daron M. Standley, Regina M. Young, Jennifer L. Brogdon, Stephan A. Grupp, Carl H. June, Shannon L. Maude, Saar Gill, Marco Ruella   +35 more
openalex   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Pathogenesis and novel therapeutics of regulatory T cell subsets and interleukin-2 therapy in systemic lupus erythematosus [PDF]

, 2023
Yi‐Giien Tsai, P. F. Liao, Kai‐Hung Hsiao, Hung‐Ming Wu, Ching‐Yuang Lin, Kuender D. Yang   +5 more
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIV [PDF]

, 2022
Marta Calvet‐Mirabent, Ildefonso Sánchez‐Cerrillo, Noa B. Martín‐Cófreces, Pedro Martínez‐Fleta, Hortensia de la Fuente, Ilya Tsukalov, Cristina Delgado‐Arévalo, Marı́a J. Calzada, Ignacio de los Santos, Jesús Sanz, Lucio García‐Fraile, Francisco Sánchez‐Madrid, Arántzazu Alfranca, María Ángeles Muñoz‐Fernández, María J. Buzón, Enrique Martín‐Gayo   +15 more
openalex   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis

, 2022
Jinyuan Luoqian, Wenyong Yang, Xulong Ding, Qing‐zhang Tuo, Zheng Xiang, Zhaoyue Zheng, Yujie Guo, Li Li, Pengbo Guan, Scott Ayton, Biao Dong, Huiyuan Zhang, Hongbo Hu, Peng Lei   +13 more
openalex   +2 more sources

Activation-inducible CAR expression enables precise control over engineered CAR T cell function [PDF]

, 2023
Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak   +9 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source