Results 151 to 160 of about 30,445,587 (352)

Molecular and cellular insights into T cell exhaustion

Nature reviews. Immunology, 2015
J. Wherry, M. Kurachi
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

Nature, 2020
N. Le Bert, A. Tan, Kamini Kunasegaran, C. Tham, Morteza Hafezi, A. Chia, M. Chng, Meiyin Lin, N. Tan, M. Linster, W. Chia, M. Chen, Lin‐Fa Wang, E. Ooi, S. Kalimuddin, P. Tambyah, J. Low, Yee-Joo Tan, A. Bertoletti   +18 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Nature, 2020
U. Şahin, A. Muik, E. Derhovanessian, I. Vogler, L. Kranz, M. Vormehr, A. Baum, Kristen E. Pascal, Jasmin Quandt, D. Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, R. Hilker, D. Becker, Ann-Kathrin Eller, J. Grützner, Carsten Boesler, Corinna Rosenbaum, Marie-Cristine Kühnle, U. Luxemburger, Alexandra Kemmer-Brück, D. Langer, M. Bexon, S. Bolte, K. Karikó, T. Palanché, Boris Fischer, A. Schultz, P. Shi, Camila R. Fontes-Garfias, John L. Perez, K. Swanson, Jakob Loschko, Ingrid L Scully, Mark Cutler, W. Kalina, C. Kyratsous, David Cooper, P. Dormitzer, K. Jansen, Ö. Türeci   +41 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

T-cell clones and T-cell receptors [PDF]

Microbiological Reviews, 1986
openaire   +2 more sources

Memory T cells [PDF]

Nature, 1989
Merkenschlager, M, Beverley, P
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Strategy of Targeted T Cell Immunotherapy for Acute Myeloid Leukemia

Zhongliu Fangzhi Yanjiu
T cell dysfunction is a common feature in patients with acute myeloid leukemia (AML). The up-regulation of immune checkpoint (IC) proteins resulting in T cell exhaustion is a key reason for T cell dysfunction.
LI Yangqiu
doaj   +1 more source