Results 231 to 240 of about 28,819,884 (406)
Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more sourceFeasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more sourceTargeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells [PDF]
, 2017 Lynsey M. Whilding, Ana C. Parente‐Pereira, Tomasz Zabinski, David M. Davies, Roseanna M. Petrovic, Y. Vincent Kao, Shobhit Saxena, Alex Romain, Jose A. Costa-Guerra, Shelia M. Violette, Hiroaki Itamochi, Sadaf Ghaem‐Maghami, Sabari Vallath, John F. Marshall, John Maher +14 moreopenalex +1 more sourceAggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more sourceClosing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans
, 2013 Liset Westera, Julia Drylewicz, Ineke den Braber, Tendai Mugwagwa, I. Maas, Lydia M. Kwast, Thomas J. H. Volman, Elise H. R. van de Weg-Schrijver, István Bartha, G. Th. Spierenburg, Koos Gaiser, Mariëtte T. Ackermans, Becca Asquith, Rob J. de Boer, Kiki Tesselaar, José A. M. Borghans +15 moreopenalex +2 more sourcesDefining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
Cell, 2018 Moshe Sade-Feldman, Keren Yizhak, Stacey L. Bjorgaard, John P. Ray, Carl G. de Boer, R. Jenkins, David J. Lieb, Jonathan H. Chen, Dennie T. Frederick, Michal Barzily-Rokni, S. Freeman, A. Reuben, P. Hoover, A. Villani, E. Ivanova, A. Portell, P. Lizotte, A. Aref, J. Eliane, Marc R. Hammond, Hans Vitzthum, S. Blackmon, Bo Li, V. Gopalakrishnan, S. Reddy, Z. Cooper, C. Paweletz, D. Barbie, A. Stemmer-Rachamimov, K. Flaherty, J. Wargo, G. Boland, R. Sullivan, G. Getz, N. Hacohen +34 moresemanticscholar +1 more sourceTumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini +12 morewiley +1 more source
