Results 321 to 330 of about 28,819,884 (406)

Neurolymphomatosis of T-Cell Origin in a Dog. [PDF]

J Vet Intern Med
Müller MK, Irmscher M, Goldbach N, Haake AFH, Kershaw O, Baloi PA.   +5 more
europepmc   +1 more source

Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells

, 2017
María Sánchez-Del Cojo, María Rosa López‐Huertas, Francisco Díez‐Fuertes, Sara Rodríguez-Mora, Mercedes Bermejo, Guillermo López–Campos, Elena Mateos, Laura Jiménez-Tormo, Francisco Gómez‐Esquer, Gema Díaz‐Gil, José Alcamı́, Mayte Coiras   +11 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Corneal Myofibroblasts Suppress T-Cell Immunity in Corneal Transplantation. [PDF]

Invest Ophthalmol Vis Sci
Wang S, Esquivel Herrera A, Elbasiony E, Lee S, Mittal SK, Dehghani S, Narimatsu A, Alemi H, Chauhan SK, Dana R, Dohlman TH.   +10 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Editorial: Achilles heel of CAR T-cell therapy. [PDF]

Front Immunol
Chiriva-Internati M, Grizzi F.
europepmc   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Induction of Lupus T Cell Subset by Probiotics-Matured Tolerogenic Dendritic Cells. [PDF]

Food Sci Nutr
Ahmadi-Khorram M, Mahmoudi M, Kheder RK, Rastin M, Hatami A, Fadaee A, Esmaeili SA.   +6 more
europepmc   +1 more source