Results 91 to 100 of about 14,398,598 (290)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A novel Vδ1 engager targeting CD19 enhances human Vδ1 γδ T cell responses against CLL and CD19+ hematological malignancies

γδ T cells are associated with favorable outcomes in many cancers likely through a mechanism of stress-directed cytotoxicity and antitumor cytokine production.
Robert Good, Katherine J Seidl, Antara Banerjee, Jessica Strid, Andrew J Hutton, Shefali A Bhumbra, Tyreese Hines   +6 more
core   +1 more source

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

, 2020
Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive.
Jiang, Jue, Han, Meng, Wang, Yanwu, Zhang, Yingchi, Feng, Hui, Zhu, Xiaofan, Qing, Guoliang, Sun, Yonghua, Wu, Chao, Yue, Ming, Cai, Xiaolian, Jiang, Peng, Wang, Tianci, Li, Peng, Liu, Hudan, Su, Hexiu, Wang, Jingchao, Xiao, Wuhan   +17 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.

, 2023
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME).
Fortin, J., Tobin, C., Mason, C.E., Leca, J., Butler, Daniel, de Leval, Laurence, Fortin, Jerome, Tobin, Chantal, Melnick, Ari, Sakamoto, Takashi, Foox, J., Gaulard, P., El Ghamrasni, Samah, Mak, Tak W., Lemonnier, F., Smith, Logan K., Sakamoto, T., Berger, T., Haight, J., Gaulard, Philippe, Mak, T.W., Mboumba, D.L., Duncan, Gordon S., Melnick, A., Butler, D., Lemonnier, Franҫois, Mason, Christopher E., Hodgson, K., Berger, Thorsten, Leca, Julie, Hodgson, Kelsey, Haight, Jillian, Meydan, C., Smith, L.K., Foox, Jonathan, Mboumba, Diana Laure, Meydan, Cem, Elia, Andrew J., El Ghamrasni, S., Duncan, G.S., Elia, A.J., de Leval, L.   +41 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

A ROR1 targeted bispecific T cell engager shows high potency in the pre-clinical model of triple negative breast cancer

Breast Cancer Research
Background Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized with poor prognosis and high metastatic potential.
Fan Wang, Weina Li, Guohui Han, Jun Xie, Xiangdong Bai   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Nano-Biohybrid DNA Engager That Reprograms the T‑Cell Receptor

Although engineered T cells with transgenic chimeric antigen receptors (CARs) have made a breakthrough in cancer therapeutics, this approach still faces many challenges in the specificity, efficacy, and self-safety of genetic engineering.
Hua-Dong Li (8405775), Bang-Ce Ye (117072), Bin-Cheng Yin (259643), Pei-Qiang Ma (8405772), Tian-Xian Liu (14193668)   +4 more
core   +1 more source

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Lane, P., T Brocker, McConnell, F., S Hubele, F McConnell, Padovan, E., P Lane, E Padovan, Lanzavecchia, A., Brocker, Thomas, A Lanzavecchia, Hubele, S.   +11 more
core   +1 more source