Results 201 to 210 of about 5,808 (257)

Perspectives on Outpatient Delivery of Bispecific T-Cell Engager Therapies for Multiple Myeloma. [PDF]

Curr Oncol
Pelland AA, Dumas M, Lemieux-Blanchard É, LeBlanc R, Côté J, Boudreault JS, Duquette D, Kaedbey R, Lalancette M, Larose F, Nikonova A, Pavic M, Shamy A, Roy J, Sebag M, Trudel S, Claveau JS.   +16 more
europepmc   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

A measles virus encoding a CD19/CD3 bispecific T cell engager shows enhanced preclinical anti-BCP-ALL efficacy without significant toxicity. [PDF]

Mol Ther Oncol
Heinze S, Stadler GL, Zhang Y, Engeland CE, Barth TFE, Heidbuechel JPW, Meyer LH, Mühlebach MD, Debatin KM, Dorneburg C, Beltinger C.   +10 more
europepmc   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Oncolytic adenoviruses encoding bispecific T cell engagers or a novel trispecific T cell engager for dual-targeting of c-MET and EGFR. [PDF]

Mol Ther Oncol
Boos MA, Seifert O, Sawall S, Genz J, Huber A, Hofmann I, Kontermann RE, Ungerechts G, Nettelbeck DM.   +8 more
europepmc   +1 more source

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring

Advanced Healthcare Materials, EarlyView.
Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio‐da‐Silva, Alireza Dolatshahi‐Pirouz, Gorka Orive   +9 more
wiley   +1 more source

Virus envelope glycoprotein targeting bispecific T cell engager protects mice from lethal severe fever with thrombocytopenia virus infection. [PDF]

Cell Rep Med
Peng X, Wang W, Liang Y, Jian Y, Wei Q, Yang T, Wang C, Yin X, Du M, Shang H, Liu R, Wang X, Shang X, Gong N, Xu Y, Wang C, Cui N, Zhang L, Guo Y, Liu W, Zhang H, Li H.   +21 more
europepmc   +1 more source

A Tissue Factor Bi-Specific T-Cell Engager Provides Effective Targeting and Cytotoxicity Against Cervical Cancer Cell Lines. [PDF]

Int J Mol Sci
Lee KJ, Kim G, Seo B, Jeong SY, Kim HS, Cho HY, Park ST.   +6 more
europepmc   +1 more source

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency. [PDF]

Proc Natl Acad Sci U S A
Leithner A, Staufer O, Mitra T, Liberta F, Valvo S, Kutuzov M, Dada H, Spaeth J, Zhou W, Schiele F, Reindl S, Nar H, Hoerer S, Crames M, Comeau S, Young D, Low S, Jenkins E, Davis SJ, Klenerman D, Nixon A, Pefaur N, Wyatt D, Dushek O, Kasturirangan S, Dustin ML.   +25 more
europepmc   +1 more source