Results 201 to 210 of about 1,626,605 (265)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens. [PDF]

EMBO J
Huhn A, Kutuzov MA, Maclean K, Uhl LFK, Mahale JM, Gérard A, van der Merwe PA, Dushek O.   +7 more
europepmc   +1 more source

Benchmarking of T cell receptor-epitope predictors with ePytope-TCR. [PDF]

Cell Genom
Drost F, Chernysheva A, Albahah M, Kocher K, Schober K, Schubert B.   +5 more
europepmc   +1 more source

A fingerprint approach to pioneer structure-based T cell receptor repertoire analysis and specificity prediction. [PDF]

Front Immunol
Mayol-Rullan F, Bugnon M, Perez MAS, Zoete V.   +3 more
europepmc   +1 more source

Safety and biologic activity of a bispecific T cell receptor targeting HIV Gag in males living with HIV: a first-in-human trial. [PDF]

Nat Commun
Vandekerckhove L, Fox J, Mora-Peris B, Navarro J, Allard SD, Uriel AJ, Moreno Guillén S, Boffito M, Post FA, Estrada V, Mothe B, Delporte M, Benlahrech A, Rahman H, Clubley J, Treveil A, Chamberlain J, Harrison R, Hock M, Yuan Y, Wustner J, Moureau S, Whale AD, Wallace Z, Singh PK, Titanji K, Dorrell L, Fidler S.   +27 more
europepmc   +1 more source

T cell-microbiome associations captured through T cell receptor convergence analysis

Vandoren R, Ha M, Van Deuren V, De Roeck N, Pu T, Brand EC, Kuznetsova M, Besbassi H, Bartholomeus E, Affaticati F, De Boeck I, Gehrmann T, Lebeer S, Oldenburg B, van Wijk F, Delputte P, Verbandt S, Tejpar S, Laukens K, Ogunjimi B, Meysman P.   +20 more
europepmc   +1 more source

Impact of anti-TB drugs on modulations of T-cell-receptor-mediated signaling events in TB pleurisy patients. [PDF]

Front Immunol
Sharma B, Joshi B, Kumar S.
europepmc   +1 more source

Correction to: SLAMF6 regulates basal T cell receptor signaling and influences invariant natural killer T cell lineage diversity. [PDF]

Int Immunol
europepmc   +1 more source

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T cell receptors

The American Journal of Medicine, 1988
Over the past few decades, a solid body of evidence has been built up linking certain autoimmune diseases to the presence of specific major histocompatibility complex haplotypes. Major histocompatibility complex products are used by the immune system to distinguish non-self from self and are important in the recognition of foreign antigen by T cells. T
N, Caccia, T W, Mak
openaire   +2 more sources

The T Cell Receptor

Science, 1987
The primary structure of T cell receptor proteins and genes is well understood. Immunologists are now trying to understand the properties of these interesting molecules. Evidence suggests that T cell αβ receptors recognize a complex of an antigen-derived peptide bound to one of the cell-surface products of the major histocompatibility complex (MHC ...
P, Marrack, J W, Kappler
openaire   +3 more sources