Results 101 to 110 of about 1,946,426 (304)

Single-cell T-cell receptor repertoire profiling in dogs

Communications Biology
Spontaneous cancers in companion dogs are robust models of human disease. Tracking tumor-specific immune responses in these models requires reagents to perform species-specific single cell T cell receptor sequencing (scTCRseq).
My H. Hoang, Zachary L. Skidmore, Hans Rindt, Shirley Chu, Bryan Fisk, Jennifer A. Foltz, Catrina Fronick, Robert Fulton, Mingyi Zhou, Nathan J. Bivens, Carol N. Reinero, Todd A. Fehniger, Malachi Griffith, Jeffrey N. Bryan, Obi L. Griffith   +14 more
doaj   +1 more source

Simultaneous profiling of the blood and gut T and B cell repertoires in Crohn’s disease and symptomatic controls illustrates tissue-specific alterations in the immune repertoire of individuals with Crohn’s disease

Frontiers in Immunology
IntroductionCrohn’s disease (CD) is a clinical subset of inflammatory bowel disease that is characterized by patchy transmural inflammation across the gastrointestinal tract. Although the exact etiology remains unknown, recent findings suggest that it is
Aya K. H. Mahdy, Valentina Schöpfel, Gert Huppertz-Hauss, Gøri Perminow, Florian Tran, Corinna Bang, Johannes R. Hov, Johannes R. Hov, Johannes R. Hov, Johannes R. Hov, May-Bente Bengtson, Petr Ricanek, Randi Opheim, Randi Opheim, Tone Bergene Aabrekk, Trond Espen Detlie, Trond Espen Detlie, Vendel A. Kristensen, Vendel A. Kristensen, Mathilde Poyet, Marte Lie Høivik, Marte Lie Høivik, Andre Franke, Hesham ElAbd, Hesham ElAbd   +24 more
doaj   +1 more source

The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion

Journal of Experimental Medicine, 2009
Memory T cells exhibit superior responses to pathogens and tumors compared with their naive counterparts. Memory is typically generated via an immune response to a foreign antigen, but functional memory T cells can also be produced from naive cells by ...
C. Haluszczak, Adovi Akue, Sara E. Hamilton, L. Johnson, L. Pujanauski, Lenka S. Teodorovic, S. Jameson, R. Kedl   +7 more
semanticscholar   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Deep Sequencing of the T-cell Receptor Repertoire Demonstrates Polyclonal T-cell Infiltrates in Psoriasis [version 1; referees: 2 approved]

F1000Research, 2015
It is well known that infiltration of pathogenic T-cells plays an important role in psoriasis pathogenesis. However, the antigen specificity of these activated T-cells is relatively unknown.
Jamie L. Harden, David Hamm, Nicholas Gulati, Michelle A. Lowes, James G. Krueger   +4 more
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Frontiers in Immunology, 2020
Meriem Attaf, Meriem Attaf, Julia Roider, Julia Roider, Julia Roider, Julia Roider, Amna Malik, Cristina Rius Rafael, Cristina Rius Rafael, Garry Dolton, Garry Dolton, Andrew J. Prendergast, Andrew J. Prendergast, Andrew J. Prendergast, Alasdair Leslie, Alasdair Leslie, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Henrik N. Kløverpris, Henrik N. Kløverpris, Andrew K. Sewell, Andrew K. Sewell, Philip J. Goulder, Philip J. Goulder   +26 more
doaj   +1 more source

A mechanism for expansion of regulatory T cell repertoire and its role in self tolerance

Nature, 2015
T-cell receptor (TCR) signalling has a key role in determining T-cell fate. Precursor cells expressing TCRs within a certain low-affinity range for complexes of self-peptide and major histocompatibility complex (MHC) undergo positive selection and ...
Yongqiang Feng, Joris van der Veeken, M. Shugay, E. Putintseva, H. Osmanbeyoglu, Stanislav Dikiy, Beatrice Hoyos, Bruno Moltedo, S. Hemmers, P. Treuting, C. Leslie, D. Chudakov, A. Rudensky   +12 more
semanticscholar   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source