Results 201 to 210 of about 27,710,413 (387)

1063 Advances in mouse models for the evaluation of T-cell engager therapeutics [PDF]

Virna Cortez‐Retamozo
openalex   +1 more source

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.

New England Journal of Medicine, 2013
Stephan A. Grupp, M. Kalos, D. Barrett, R. Aplenc, David L. Porter, S. Rheingold, D. Teachey, A. Chew, B. Hauck, J. Fraser Wright, Michael C. Milone, Bruce L. Levine, Carl H June   +12 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

T cells in ITP: Focus on T follicular helper cells and cytotoxic T cells. [PDF]

Br J Haematol
Audia S, Cooper N.
europepmc   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Functionally heterogeneous intratumoral CD4⁺CD8⁺ double-positive T cells can give rise to single-positive T cells. [PDF]

Proc Natl Acad Sci U S A
Li T, Ilano A, Arias-Badia M, Luong D, Chang H, Kwek SS, Allaire K, Chumber A, Sakamoto M, Clark M, Lea A, Bridge M, Chen B, Liu E, Porten S, Meng MV, Erlich LIR, Oh DY, Fong L.   +18 more
europepmc   +1 more source

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

Nature reviews. Drug discovery, 2020
S. Depil, P. Duchateau, S. Grupp, G. Mufti, L. Poirot   +4 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Pattern of Regulatory T Cells, Resident Memory T Cells, and Exhausted T Cells in Human Pericardial Fluid Samples of Cardiovascular Patients. [PDF]

Int J Mol Sci
Érsek B, Opra J, Fekete N, Ifju M, Molnár V, Bugyik E, Pállinger É, Székely A, Radovits T, Merkely B, Buzás EI.   +10 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source