Results 201 to 210 of about 7,436,963 (336)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Tetraspan(in)-mediated immune regulation in hepatocellular carcinoma: Editorial on “Targeting TM4SF1 promotes tumor senescence enhancing CD8 T cell cytotoxic function in hepatocellular carcinoma” [PDF]

Clinical and Molecular Hepatology
Seo Hee Jin, Dong Joo Kim, Jung Weon Lee
doaj   +1 more source

γδ T cells are the prime antitumoral T cells in pediatric neuroblastoma. [PDF]

Life Sci Alliance
Castenmiller SM, Borst AL, Wardak L, Molenaar JJ, Papadopoulou M, de Krijger RR, van der Steeg AF, van Noesel MM, Vermijlen D, de Groot R, Wienke J, Wolkers MC.   +11 more
europepmc   +1 more source

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

, 2011
Ting Feng, Anthony Cao, Casey T. Weaver, Charles O. Elson, Yingzi Cong   +4 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells [PDF]

, 2017
Lynsey M. Whilding, Ana C. Parente‐Pereira, Tomasz Zabinski, David M. Davies, Roseanna M. Petrovic, Y. Vincent Kao, Shobhit Saxena, Alex Romain, Jose A. Costa-Guerra, Shelia M. Violette, Hiroaki Itamochi, Sadaf Ghaem‐Maghami, Sabari Vallath, John F. Marshall, John Maher   +14 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Triglycerides and T Cells in Cardiovascular Risk: Inflammatory Transcriptomic Profile in Hypertriglyceridemia Patients' T Cells. [PDF]

JACC Basic Transl Sci
Reilly NA, Mulder JWCM, Dekkers KF, Kuipers TB, van Vark-van der Zee LC, Mulder MT, Roeters van Lennep JE, Jukema JW, Heijmans BT.   +8 more
europepmc   +1 more source

Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

, 2013
Liset Westera, Julia Drylewicz, Ineke den Braber, Tendai Mugwagwa, I. Maas, Lydia M. Kwast, Thomas J. H. Volman, Elise H. R. van de Weg-Schrijver, István Bartha, G. Th. Spierenburg, Koos Gaiser, Mariëtte T. Ackermans, Becca Asquith, Rob J. de Boer, Kiki Tesselaar, José A. M. Borghans   +15 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source