Results 241 to 250 of about 27,710,413 (387)

A Humanizing Rewrite for CAR T Cells in Autoimmune Disease: A StepToward Repeatable, Durable Therapy

Samia Chergui
openalex   +2 more sources

Developing in vitro expanded CD45RA⁺regulatory T cells as an adoptive cell therapy for Crohn's disease [PDF]

, 2015
James B. Canavan, Cristiano Scottà, Anna Vossenkämper, Rimma Goldberg, Matthew J. Elder, Irit Shoval, Ellen Marks, Émilie Stolarczyk, Jonathan W. Lo, Nick Powell, Henrieta Fazekasova, Peter M. Irving, Jeremy Sanderson, Jane K. Howard, Simcha Yagel, Behdad Afzali, Thomas T. MacDonald, María P. Hernández-Fuentes, Nahum Y. Shpigel, Giovanna Lombardi, Graham M. Lord   +20 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

CAR-T cells immunotherapy in the treatment of glioblastoma. [PDF]

Cancer Immunol Immunother
Królikowska A, Tarnowski M.
europepmc   +1 more source

MBNL loss facilitates resistance to T cell infiltration in vivo.

Austin M. Gabel (15162431), Edie I. Crosse (21221895), Andrea E. Belleville (19434726), Simon J. Hogg (13173232), Siegen A. McKellar (21221898), Omar Abdel-Wahab (4033136), James D. Thomas (15162413), Robert K. Bradley (8700927)   +7 more
openalex   +1 more source

NAD+ Released during Inflammation Participates in T Cell Homeostasis by Inducing ART2-Mediated Death of Naive T Cells In Vivo [PDF]

, 2007
Sahil Adriouch, Sandra Hubert, Sèverine Pechberty, Friedrich Koch‐Nolte, Friedrich Haag, Michel Séman   +5 more
openalex   +1 more source

CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

Journal of Clinical Investigation, 2016
C. Turtle, L. Hanafi, C. Berger, T. Gooley, S. Cherian, M. Hudecek, D. Sommermeyer, Katherine Melville, B. Pender, Tanya M Budiarto, E. Robinson, Natalia N Steevens, Colette N. Chaney, L. Soma, Xueyan Chen, C. Yeung, B. Wood, Daniel H. Li, Jianhong Cao, S. Heimfeld, M. Jensen, S. Riddell, D. Maloney   +22 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vivo engineering of CAR-T cells: delivery strategies and clinical translation. [PDF]

Biomark Res
Gao Y, Hu J, An N, Wen X, Li C.
europepmc   +1 more source

Image 3_Urokinase-type plasminogen activator deficiency enhances CD8+ T cell infiltration and anti-PD-1 therapy efficacy in prostate cancer.tif

Xiaoyi Li (669720), Xiao Zhang (152326), Xing Fu (42224), Hong Wu (105254), Xinyu Ye (401069), Xin Huang (11077), Yuhao Cui (22152538), Chao-Nan Qian (248097), Yi Lu (6211), Jian Zhang (1682)   +9 more
openalex   +1 more source