Results 241 to 250 of about 27,916,234 (409)

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

open access: yesNature Immunology, 2019
Brian C. Miller   +40 more
semanticscholar   +1 more source

A Human Leukemia Cell with Both B and T Cell Surface Receptors [PDF]

open access: green, 1974
Ethan M. Shevach   +4 more
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

open access: yesScience, 2011
K. Atarashi   +16 more
semanticscholar   +1 more source

Enhanced conversion of T cells into CAR T cells by modulation of the MAPK/ERK pathway. [PDF]

open access: yesCell Rep Med
Adabi E   +5 more
europepmc   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

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