Results 281 to 290 of about 7,436,963 (336)

Multiplex engineering and multifunction T cells for precise and effective immunotherapies. [PDF]

Front Immunol
Jafarzadeh L, Smaani A, Delisle JS.
europepmc   +1 more source

Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells

, 2017
María Sánchez-Del Cojo, María Rosa López‐Huertas, Francisco Díez‐Fuertes, Sara Rodríguez-Mora, Mercedes Bermejo, Guillermo López–Campos, Elena Mateos, Laura Jiménez-Tormo, Francisco Gómez‐Esquer, Gema Díaz‐Gil, José Alcamı́, Mayte Coiras   +11 more
openalex   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

γδ T cells and resistance to CDK4/6 inhibitors in breast cancer. [PDF]

Cell Death Dis
Kepp O, Kroemer G.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

LUBAC modulates CBM complex functions downstream of TRAF6 in T cells. [PDF]

Nat Commun
Graß C, Ober F, Sixt C, Moud BN, Antoshkina I, Eberstadt F, Puhach A, Avar G, Keßler A, O'Neill TJ, Seeholzer T, Kranich J, Brocker T, Lammens K, Menden MP, Zielinski CE, Krappmann D.   +16 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Follicular Helper T Cells: Potential Interventional Targets in Atherosclerosis. [PDF]

J Immunol Res
Chen Y, Wang W, Xia X, Xu X, Wang S, Gurumallesh P.   +5 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

ceRNA regulatory network and immune-neurodegenerative mechanisms of peripheral CD4+ T cells in parkinson's disease. [PDF]

PLoS One
Guo L, Li Q, Li J, Yang F.
europepmc   +1 more source