Results 331 to 340 of about 27,710,413 (387)
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Pan-cancer single-cell landscape of tumor-infiltrating T cells
Science, 2021Description An atlas of cancer-associated T cells The tumor microenvironment contains many different kinds of immune cells, the composition, function, and roles of which are unclear.
Liangtao Zheng +18 more
semanticscholar +1 more source
2020
In 1891, Dr. William B. Coley, an American surgeon, made a compelling observation that immune system can be triggered to shrink tumors. The quest to exploit the power of immunotherapy however was forestalled by an era of chemotherapy that ensued.
Ranjit, Nair, Jason, Westin
openaire +3 more sources
In 1891, Dr. William B. Coley, an American surgeon, made a compelling observation that immune system can be triggered to shrink tumors. The quest to exploit the power of immunotherapy however was forestalled by an era of chemotherapy that ensued.
Ranjit, Nair, Jason, Westin
openaire +3 more sources
Cytokine Regulation and Function in T Cells.
Annual Review of Immunology, 2021T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune responses to mediate inflammation and regulate other types of immune cells.
C. Dong
semanticscholar +1 more source
T-cell therapies for T-cell lymphoma
Cytotherapy, 2019T-cell lymphomas represent a subpopulation of non-Hodgkin lymphomas with poor outcomes when treated with conventional chemotherapy. A variety of novel agents have been introduced as new treatment strategies either as first-line treatment or in conjunction with chemotherapy. Immunotherapy has been demonstrated to be a promising area for new therapeutics,
Keri Toner +2 more
openaire +2 more sources
T Cell Receptors and T Cell Development
1996Birds provide a valuable model system for the study of early development. Studies of immune system development and function in chickens have contributed to some of the central tenets in immunology. These include:(1) allorecognition by lymphocytes in graft-vs-host (GVH) reactions (Simonsen 1985), (2) clonal reactivity of immunocompetent lymphocytes ...
C H, Chen +6 more
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The Journal of Immunology, 1972
Abstract The antigen-induced DNA synthetic response of a number of different thymocyte populations was studied in the spleens of lethally irradiated recipients by incorporation of 125I 5-iodo-2-deoxyuridine. The response of certain cell combinations was not only less than the sum of the two responding alone but less than one of the ...
Gershon, R K +3 more
openaire +2 more sources
Abstract The antigen-induced DNA synthetic response of a number of different thymocyte populations was studied in the spleens of lethally irradiated recipients by incorporation of 125I 5-iodo-2-deoxyuridine. The response of certain cell combinations was not only less than the sum of the two responding alone but less than one of the ...
Gershon, R K +3 more
openaire +2 more sources
T-Cell Receptor–Transduced T Cells
The Cancer Journal, 2015The large number of T-cell epitopes that have been found to be processed and presented on human tumors, now numbering in the hundreds, provides a rich source of targets for therapeutic interventions aimed at inducing durable tumor regression. Vaccination strategies aimed at inducing responses to these antigens have been largely ineffective, and it has ...
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The American Journal of Medicine, 1988
Over the past few decades, a solid body of evidence has been built up linking certain autoimmune diseases to the presence of specific major histocompatibility complex haplotypes. Major histocompatibility complex products are used by the immune system to distinguish non-self from self and are important in the recognition of foreign antigen by T cells. T
N, Caccia, T W, Mak
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Over the past few decades, a solid body of evidence has been built up linking certain autoimmune diseases to the presence of specific major histocompatibility complex haplotypes. Major histocompatibility complex products are used by the immune system to distinguish non-self from self and are important in the recognition of foreign antigen by T cells. T
N, Caccia, T W, Mak
openaire +2 more sources
New England Journal of Medicine, 2011
The pursuit of tumor-reactive T cells as a cancer therapy has continued unabated since the discovery of the graft-versus-leukemia effect in patients undergoing allogeneic hematopoietic stem-cell transplantation.1 Some successes have been noted: the adoptive transfer of Epstein–Barr virus (EBV)–specific T cells can prevent and treat post-transplantation
Walter J, Urba, Dan L, Longo
openaire +2 more sources
The pursuit of tumor-reactive T cells as a cancer therapy has continued unabated since the discovery of the graft-versus-leukemia effect in patients undergoing allogeneic hematopoietic stem-cell transplantation.1 Some successes have been noted: the adoptive transfer of Epstein–Barr virus (EBV)–specific T cells can prevent and treat post-transplantation
Walter J, Urba, Dan L, Longo
openaire +2 more sources