Results 351 to 360 of about 27,710,413 (387)
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Current Opinion in Immunology, 2004
Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation.
Fernando, Macián +3 more
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Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation.
Fernando, Macián +3 more
openaire +2 more sources
Scientific American, 1993
T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen encounter, but remains alive for an extended period of time in a hyporesponsive state. Models of T cell anergy affecting both CD4+and CD8+cells fall into two broad categories.
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T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen encounter, but remains alive for an extended period of time in a hyporesponsive state. Models of T cell anergy affecting both CD4+and CD8+cells fall into two broad categories.
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Current Opinion in Immunology, 1998
Major histocompatibility complex (MHC) molecules in the thymus select from the repertoire of germline receptors those that will be most useful in mounting responses to antigen in the periphery. Recent data has shed light on the involvement of self peptides presented by the MHC in this process, and has indicated that a requirement for the constant ...
S C, Jameson, M J, Bevan
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Major histocompatibility complex (MHC) molecules in the thymus select from the repertoire of germline receptors those that will be most useful in mounting responses to antigen in the periphery. Recent data has shed light on the involvement of self peptides presented by the MHC in this process, and has indicated that a requirement for the constant ...
S C, Jameson, M J, Bevan
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2006
T cell memory induced by prior infection or vaccination provides enhanced protection against subsequent microbial infections. The processes involved in generating and maintaining T cell memory are becoming better understood due to recent technological advances in identifying memory T cells and monitoring their behavior and function in vivo.
J T, Tan, C D, Surh
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T cell memory induced by prior infection or vaccination provides enhanced protection against subsequent microbial infections. The processes involved in generating and maintaining T cell memory are becoming better understood due to recent technological advances in identifying memory T cells and monitoring their behavior and function in vivo.
J T, Tan, C D, Surh
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Frontiers in Bioscience, 2007
Adoptive T cell immunotherapy is the isolation of tumor-specific T cells from a cancer patient, in vitro activation and expansion of these T cells, and re-infusion of the T cells to the patient. In a small percentage of patients with tumor types susceptible to immune modulation, adoptive therapy has proven to be highly effective.
Mark D, McKee +2 more
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Adoptive T cell immunotherapy is the isolation of tumor-specific T cells from a cancer patient, in vitro activation and expansion of these T cells, and re-infusion of the T cells to the patient. In a small percentage of patients with tumor types susceptible to immune modulation, adoptive therapy has proven to be highly effective.
Mark D, McKee +2 more
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2007
T cell therapies are increasingly used for the treatment of malignancies and viral-associated diseases. Initial studies focused on the use of unmanipulated T cell populations after allogeneic stem cell transplantation. More recently, the use of antigen-specific T cells has been explored.
S, Gottschalk +8 more
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T cell therapies are increasingly used for the treatment of malignancies and viral-associated diseases. Initial studies focused on the use of unmanipulated T cell populations after allogeneic stem cell transplantation. More recently, the use of antigen-specific T cells has been explored.
S, Gottschalk +8 more
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Current Opinion in Immunology, 1988
The miracle of the immune system is its ability to distinguish between self and non-self. This has puzzled immunologists for years and will continue to do so. The simplest explanation was provided by Burnet’s theoty of clonal selection, which claimed that forbidden autoreactive clones are removed by some magic intrathymic process.
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The miracle of the immune system is its ability to distinguish between self and non-self. This has puzzled immunologists for years and will continue to do so. The simplest explanation was provided by Burnet’s theoty of clonal selection, which claimed that forbidden autoreactive clones are removed by some magic intrathymic process.
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Trends in Microbiology, 1999
The T-cell immune response to infectious agents has been polarized into two opposing subsets of T cells: Th1 T cells, which produce interferon γ and are important against viruses and intracellular bacteria, and Th2 T cells, which produce interleukin 4 and interleukin 10, stimulate the humoral immune response and are important against extracellular ...
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The T-cell immune response to infectious agents has been polarized into two opposing subsets of T cells: Th1 T cells, which produce interferon γ and are important against viruses and intracellular bacteria, and Th2 T cells, which produce interleukin 4 and interleukin 10, stimulate the humoral immune response and are important against extracellular ...
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2014
The role of allergen-specific CD4+ effector type 2 helper (Th2) cells in the pathogenesis of allergic disorders is an established fact. Th2 cells produce interleukin (IL)-4 and IL-13, which induce immunoglobulin E production by B cells, and IL-5 that allows recruitment of eosinophils.
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The role of allergen-specific CD4+ effector type 2 helper (Th2) cells in the pathogenesis of allergic disorders is an established fact. Th2 cells produce interleukin (IL)-4 and IL-13, which induce immunoglobulin E production by B cells, and IL-5 that allows recruitment of eosinophils.
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