Results 151 to 160 of about 469,115 (308)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Efficient Magic State Cultivation on RP^{2}
PRX QuantumPreparation of high-fidelity logical magic states is crucial for fault-tolerant quantum computation. Among previous attempts to reduce the substantial cost of magic state preparation, magic state cultivation (MSC) [Gidney et al., Magic state cultivation:
Zi-Han Chen +3 more
doaj +1 more source
Quantum Information ProcessingAbstractCSS-T codes were recently introduced as quantum error-correcting codes that respect a transversal gate. A CSS-T code depends on a CSS-T pair, which is a pair of binary codes $$(C_1, C_2)$$ ( C 1 ,
Eduardo Camps-Moreno +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Threshold decoding of hospitals self-original conventional codes
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The efficiency of threshold decoding of non-binary self-orthogonal convolutional codes in the communication channel with additive white Gaussian noise with the correction of t (t ≥ 1) symbolic errors is considered.
E. G. Makeichik +2 more
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Properties and applications of G-orbits polynomial invariants of errors in reverse codes
Журнал Белорусского государственного университета: Математика, информатика, 2019 In this paper is described a twostep procedure for polynomialnorm error correction with reverse error correcting codes. Such codes of length n traditionally are defined by check matrix HR = (βi,β−i)T, 0 ≤ i ≤ n – 1, β = α(2m−1)/n and α is ...
Alexander V. Kushnerov +1 more
doaj
, 2002 Turbo equalizers have been shown to be successful in mitigating the effects of inter-symbol interference introduced by partial response modems and by dispersive channels for code rates of $R \le 1/2$.
Hamorsky, J. +3 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source