Results 281 to 290 of about 12,046,757 (352)
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Imidazole-based Synthetic Lipidoids for In Vivo mRNA Delivery into Primary T Lymphocytes.
Angewandte Chemie, 2020Engineering T lymphocytes is an emerging approach in a variety of biomedical applications. However, delivering large biologics to primary T lymphocytes directly in vivo is technically challenging due to the low transfection efficacy.
Xuewei Zhao +5 more
semanticscholar +1 more source
Cellular and Molecular Life Sciences CMLS, 1999
Immunological memory protects organisms from recurrent challenge by pathogens. The persistence of a heightened reactive state initiated by antigenic challenge is mediated by long-lived memory lymphocytes. The survival of memory T cells is thought to require stimulation through the T cell receptor (TCR), sometimes by persistent antigen.
P G, Ashton-Rickardta, J T, Opferman
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Immunological memory protects organisms from recurrent challenge by pathogens. The persistence of a heightened reactive state initiated by antigenic challenge is mediated by long-lived memory lymphocytes. The survival of memory T cells is thought to require stimulation through the T cell receptor (TCR), sometimes by persistent antigen.
P G, Ashton-Rickardta, J T, Opferman
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CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review
Journal of Cellular Physiology, 2018CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with ...
Bagher Farhood, M. Najafi, K. Mortezaee
semanticscholar +1 more source
Annual Review of Immunology, 1983
To date, the most successful uses of T-cell clones have been in the demonstration that a single type of cell can perform multiple functions. However, their potential usefulness is enormous, and the study of cell interactions using clonal populations has just begun.
C G, Fathman, J G, Frelinger
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To date, the most successful uses of T-cell clones have been in the demonstration that a single type of cell can perform multiple functions. However, their potential usefulness is enormous, and the study of cell interactions using clonal populations has just begun.
C G, Fathman, J G, Frelinger
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Scandinavian Journal of Gastroenterology, 1995
The intestine is largely colonized by bacteria and further exposed to an immense array of ingested and shed immunogenic material. Therefore, the gut associated lymphoid tissue plays a major role in the human immune system. It may even constitute a unique immune system of its own, since it has been demonstrated to differ anatomically, phenotypically ...
R J, Robijn +5 more
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The intestine is largely colonized by bacteria and further exposed to an immense array of ingested and shed immunogenic material. Therefore, the gut associated lymphoid tissue plays a major role in the human immune system. It may even constitute a unique immune system of its own, since it has been demonstrated to differ anatomically, phenotypically ...
R J, Robijn +5 more
openaire +2 more sources
Annual Review of Immunology, 1983
observations and their interpretation becomes blurred with time. A re-evaluation of the data on CTL may become important at a time when the emphasis of the questions asked about these cells changes. We think the discovery of T-cell growth factor and the design of methods that have allowed the maintenance of CTL clones in permanent culture have ushered ...
M, Nabholz, H R, MacDonald
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observations and their interpretation becomes blurred with time. A re-evaluation of the data on CTL may become important at a time when the emphasis of the questions asked about these cells changes. We think the discovery of T-cell growth factor and the design of methods that have allowed the maintenance of CTL clones in permanent culture have ushered ...
M, Nabholz, H R, MacDonald
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Gut intraepithelial T lymphocytes
Current Opinion in Immunology, 1993The gut mucosa, given its length, contains a very large number of T lymphocytes in the Peyer's patches and disseminated all along the mucosa. The most conspicuous element of this last compartment, the gut intraepithelial lymphocytes, represents a population of CD8+ T lymphocytes as large as that found in the largest lymphoid organ, the spleen. In spite
D, Guy-Grand, P, Vassalli
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T Lymphocytes Degrade Fibronectin
Scandinavian Journal of Immunology, 1991Mononuclear cells cause disappearance of fibronectin synthesized and released by fibroblasts. This disappearance of extracellular fibroblast fibronectin is accompanied by the appearance of components of “lower” molecular weight indicating that a fibronectin‐degrading enzymatic activity is responsible for the effect. Additional support for the existence
S E, Bergström +2 more
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Early T Lymphocyte Progenitors
Annual Review of Immunology, 1996The earliest steps along the pathway leading to T cells in mice and humans are reviewed. These are the steps between the multipotent hemopoietic stem cell (HSC) and the fully committed precursors undergoing T cell receptor (TCR) gene rearrangement. At this level significant differences between adult and fetal lymphopoiesis have been demonstrated.
K, Shortman, L, Wu
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