Results 81 to 90 of about 12,899,769 (365)

Lymphocytes in Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
Atherosclerosis is the major cause of cardiovascular disease, and cardiovascular disease remains the primary cause of death in the United States. The primary complication for patients with type 2 diabetes mellitus (T2D) is cardiovascular disease.1–8 Because the incidences of T2D and obesity are drastically increasing in the United States and now ...
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cytogenetic Changes in T Lymphocytes in Miners

Общая реаниматология, 2007
Objective: to study the impact of chromium levels on cytogenetic impairments in T lymphocytes in miners from the south of Kuzbass.Subjects and methods. Peripheral blood leukocytes were cultured, as described by P. S.
A. V. Makhalin, L. Yu. Redkokasha, V. V. Moroz, Yu. A. Churlyaev, N. N. Ilyinskikh, M. S. Romanova   +5 more
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes

Journal of Experimental Medicine, 1996
A human receptor that is selective for the CXC chemokines IP10 and Mig was cloned and characterized. The receptor cDNA has an open reading frame of 1104-bp encoding a protein of 368 amino acids with a molecular mass of 40,659 dalton.
M. Loetscher, B. Gerber, P. Loetscher, Simon A. Jones, L. Piali, I. Clark‐Lewis, M. Baggiolini, B. Moser   +7 more
semanticscholar   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Influence of the biophosphomag preparation and biologically active substances from milk thistle seeds (Silybum marianum) on the metabolism of lymphocytes and their functional features

Біологічні студії
Background. The OVA and patented OVA+ preparations (produced by NULES of Ukraine) were obtained according to O. V. Arnauta et al. (2021) by extracting biologically active compounds from the seeds of milk thistle (Silybum marianum) using corn oil.
Petro Fedyshyn, Olga Pavliuk, Ivan Stupak, Taisa Dovbynchuk, Yulia Pysmenna, Volodymyr Liashenko, Natalia Senchylo, Serhii Holopura, Liliia Kalachniuk, Liudmyla Garmanchuk   +9 more
doaj   +1 more source

FUNCTIONAL AORTIC STIFFNESS:ROLE OF CD4+ T LYMPHOCYTES

Frontiers in Physiology, 2015
The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte ...
Beenish A. Majeed, Lance S. Eberson, Supannikar eTawinwung, Nicolas eLarmonier, Timothy W. Secomb, Douglas F Larson   +5 more
doaj   +1 more source

Transcriptional Reprogramming of Mature CD4+ T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes

Nature Immunology, 2013
TCRαβ thymocytes differentiate into either CD8αβ+ cytotoxic T lymphocytes or CD4+ helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic ...
D. Mucida, M. M. Husain, Sawako Muroi, F. van Wijk, Ryo Shinnakasu, Y. Naoe, B. Reis, Yujun Huang, F. Lambolez, Michael Docherty, A. Attinger, J. Shui, Gisen Kim, C. Lena, S. Sakaguchi, Chizuko Miyamoto, Peng Wang, K. Atarashi, Yunji Park, T. Nakayama, K. Honda, W. Ellmeier, M. Kronenberg, I. Taniuchi, H. Cheroutre   +24 more
semanticscholar   +1 more source