Results 71 to 80 of about 11,697,514 (297)

Description of the immune microenvironment of chondrosarcoma and contribution to progression

OncoImmunology, 2017
Chondrosarcoma (CHS) is a rare bone malignancy characterized by its resistance to conventional systemic and radiation therapies. Whether immunotherapy targeting immune checkpoints may be active in these tumors remains unknown.
François A. Simard, Iseulys Richert, Alexandra Vandermoeten, Anne-Valérie Decouvelaere, Jean-Philippe Michot, Christophe Caux, Jean-Yves Blay, Aurélie Dutour   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Late-phase expression of a murine cytomegalovirus immediate-early antigen recognized by cytolytic T lymphocytes [PDF]

, 1986
The cloned murine cytolytic T-lymphocyte line IE1-IL and several sublines detect a murine cytomegalovirus immediate-early (IE) membrane determinant in conjunction with Ld class I major histocompatibility glycoprotein.
Reddehase, Matthias J., Fibi, Mathias R., Koszinowski, Ulrich H., Keil, Günther M.   +3 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Impacts of tacrolimus and glucocorticoids on peripheral blood T and B lymphocyte subsets in myasthenia gravis

Frontiers in Immunology
BackgroundThis study aimed to investigate the impact of tacrolimus on peripheral T and B lymphocyte subsets in myasthenia gravis (MG) patients compared to glucocorticoid treatment.MethodsThis study retrospectively included MG patients at the First ...
Xuan Wu, Xuan Wu, Wei Chen, Wei Chen, Huanhuan Song, Guorong Xu, Guorong Xu   +6 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Optimisation de l'activité anti-tumorale des lymphocytes T gamma9delta 2 humains [PDF]

, 2008
Si tous les vertébrés possèdent des lymphocytes T gamma delta, seuls les primates ont une sous-population sanguine exprimant un récepteur de type TCR Vgamma9Vdelta2.
Gertner-Dardenne, Julie
core  

Inflammatory and immune variables as predictors of survival in dogs with myxomatous mitral valve disease

BMC Veterinary Research
Background We aimed to investigate the association between selected inflammatory and immune variables and survival of dogs with myxomatous mitral valve disease (MMVD).
Martina Cimerman, Natalia Druzhaeva, Alenka Nemec Svete, Melita Hajdinjak, Katka Pohar, Alojz Ihan, Aleksandra Domanjko Petrič   +6 more
doaj   +1 more source

Tweaking the Complex Fibrogenic Role of Lymphocytes in Idiopathic Pulmonary Fibrosis [PDF]

Tuberculosis and Respiratory Diseases
Idiopathic pulmonary fibrosis is a deadly lung disease primarily affecting aged individuals. Even though there are two U.S. Food and Drug Administration-approved drugs, nintedanib and pirfenidone, with a recent addition of another drug, nerandomilast ...
Aritra Bhattacharyya, Julie D. Saba
doaj   +1 more source