Results 51 to 60 of about 11,697,514 (297)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Classification of T lymphocyte motility behaviors using a machine learning approach.

PLoS Computational Biology, 2023
T lymphocytes migrate into organs and interact with local cells to perform their functions. How human T lymphocytes communicate with organ-specific cells and participate in pathobiological processes remains unresolved. Brain infiltration of T lymphocytes
Yves Carpentier Solorio, Florent Lemaître, Bassam Jabbour, Olivier Tastet, Nathalie Arbour, Elie Bou Assi   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]

, 2012
In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Ciudad i Gómez, Carlos Julián, Castellote i Bargalló, M. Cristina, Castell, Margarida, Noé Mata, Verónica, Rabanal i Tornero, Manel, Pelegrí, Carme, Franch, Àngels   +6 more
core   +1 more source

Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands [PDF]

, 1992
Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a ...
Pavic, Ivica, Koszinowski, Ulrich H., Koszinowski, U H, Lucin, Pero, Polic, Bojan, Jonjic, Stipan   +5 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi [PDF]

, 2015
Depression affects 10-15% of pregnant women and has been associated with preterm delivery and later developmental, behavioural and learning disabilities.
Massart, R., Steiner, M., Hallett, M., Suderman, M., Li, T., Sun ZS, Sun, Z. S., Nemoda, Zsófia, Soares CN, Suderman M, Cody N, Turecki, G., Szyf, M., Szyf M, Cody, N., Soares, C. N., Li T, Turecki G, Hallett M, Nemoda, Z., Steiner M, Massart R, Coote M, Coote, M.   +23 more
core   +1 more source

A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection [PDF]

, 1988
The nonstructural immediate-early protein pp89 of murine cytomegalovirus (MCMV) is the first viral protein synthesized after infection and has a regulatory function in viral gene expression. Despite its localization in the nucleus of infected cells, pp89
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Keil, Günther M., Jonjic, Stipan   +4 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source