Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host [PDF]
, 1988 We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that CMV infection interferes with the earliest detectable step in hemopoiesis, the generation of the stem cell CFU-S-I, and thereby prevents the ...
Busch, Friedrich W. +4 more
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B lymphocytes secrete antigen-presenting vesicles
Journal of Experimental Medicine, 1996 Antigen-presenting cells contain a specialized late endocytic compartment, MIIC (major histocompatibility complex [MHC] class II- enriched compartment), that harbors newly synthesized MHC class II molecules in transit to the plasma membrane. MIICs have a
G. Raposo +6 more
semanticscholar +1 more source
Cytotoxic T Lymphocytes in Rasmussen’s Encephalitis
Pediatric Neurology Briefs, 2002 The role of cytotoxic T lymphocytes and other mechanisms in the pathogenesis of Rasmussen’s encephalitis (RE) is reviewed at the University of Vienna, Austria, and the University of Bonn, Germany.
J Gordon Millichap
doaj +1 more source
Equine herpesvirus 1 bridles T lymphocytes to reach its target organs [PDF]
, 2019 Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic
Azab, Walid +7 more
core +1 more source
Role of CTLA4 immunohistochemistry in the diagnosis of colon cancers
Indian Journal of Pathology and Microbiology, 2022 Background: There are a wide range of diagnostic markers for colorectal cancers like detection of mutated KRAS, TP53, and APC genes. However, genetic and immunological factors have also been attributed to the cancer prognosis.
Vishnu Narayanan +4 more
doaj +1 more source
Methods and compositions for stimulating T-lymphocytes [PDF]
, 2003 Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes.
Fisk, Bryan A. +2 more
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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes
Nature Medicine, 2015 Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking therapeutic effects in solid tumors than in lymphoid malignancies.
Ignazio Caruana +8 more
semanticscholar +1 more source
European Journal of Medical Research, 2017 Background T lymphocytes exert important homeostatic functions in the healthy intestinal mucosa, whereas in case of colorectal cancer (CRC), infiltration of T lymphocytes into the tumor is crucial for an effective anti-tumor immune response.
Ann-Britt Löfroos +3 more
doaj +1 more source
Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. [PDF]
, 2015 Experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), is characterized by CNS demyelination mediated by autoreactive T cells.
Deng, Wenbin +5 more
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Lipoprotein(a), its autoantibodies, and circulating T lymphocyte subpopulations as independent risk factors for coronary artery atherosclerosis [PDF]
Терапевтический архив, 2016 Aim. To study the role of lipoprotein(a) [Lp(a)] as a potential autoantigen causing the activation of immunocompetent cells in atherosclerosis. Subjects and methods.
O I Afanasievа +9 more
doaj +1 more source