CRISPR/Cas9 technology: towards a new generation of improved CAR-T cells for anticancer therapies
Briefings in Functional Genomics, 2019 AbstractChimeric antigen receptor (CAR)-modified T cells have raised among other immunotherapies for cancer treatment, being implemented against B-cell malignancies. Despite the promising outcomes of this innovative technology, CAR-T cells are not exempt from limitations that must yet to be overcome in order to provide reliable and more efficient ...
Guillermo, Ureña-Bailén +9 more
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The consequence of school performance measures – inequality of access and opportunity [PDF]
, 2017 This paper assesses the potential impact of two performance measures on equality of access to a general education for all pupils. It argues that government policy, which on the surface appears to facilitate equality of opportunity, is in fact ...
Hardy, A
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Transposon-Based CAR T Cells in Acute Leukemias: Where Are We Going?
Cells, 2020 Chimeric Antigen Receptor (CAR) T-cell therapy has become a new therapeutic reality for refractory and relapsed leukemia patients and is also emerging as a potential therapeutic option in solid tumors. Viral vector-based CAR T-cells initially drove these
Chiara F. Magnani +6 more
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Role of Dietary Flavonoid Compounds in Driving Patterns of Microbial Community Assembly
mBio, 2019 Flavonoids are a group of polyphenolic dietary compounds found in many different plant-based foods. There is increasing evidence that higher flavonoid intake may be causally linked to a reduced risk of cardiovascular disease and other chronic diseases ...
Kerry L. Ivey +5 more
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STUDENTS’ FEEDBACK FOR CONTINUOUS QUALITY IMPROVEMENT OF MATERIALS TECHNOLOGY COURSE OUTCOMES VIA TEACHING & SUPERVISION EVALUATION SYSTEM [PDF]
Journal of Engineering Science and Technology, 2016 Continuous quality improvement (CQI) of a program design and curriculum is a mandatory process to ensure the accreditation of engineering programmes. The most inner loop in CQI of a programme is the improvement of outcomes for each course offered in the ...
MOHD HUZAIRI JOHARI +2 more
doaj
Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program [PDF]
, 2016 12 p.-6 fig.1 tab.Tomokatsu Ikawa, et al.In general, cell fate is determined primarily by transcription factors, followed by epigenetic mechanisms fixing the status.
Ikawa, Tomokatsu +2 more
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Environmental Science and Technology LettersSustainable water management is essential to increasing water availability and decreasing water pollution. The wastewater sector is expanding globally and beginning to incorporate technologies that recover nutrients from wastewater.
Jennifer B. Dunn +10 more
semanticscholar +1 more source
The regulatory networks and mechanisms of bone microenvironment in tumorigenesis and metastasis
Journal of Bone OncologyBone tumors, encompassing heterogeneous primary and metastatic lesions, are driven in their initiation, progression, and metastasis by dysregulation of the bone microenvironment (BME).
Guofang Huang +3 more
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Indicators of Innovation Climate in Russia (Results of Mass Population Surveys)
Foresight and STI Governance, 2010 Сontemporary innovation policies are based mostly on the results of statistical and sociological studies for companies and expert surveys. However, the problem of motivating innovation activity is unlikely to be solved without taking into consideration ...
Olga Shuvalova
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Terahertz Beam Steering Using a MEMS-Based Reflectarray Configured by a Genetic Algorithm
IEEE Access, 2022 With the increase in potential uses of terahertz technology, the need for terahertz transceivers with application-oriented adaptive radiation patterns has emerged.
Xuan Liu +10 more
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